Entry - *138243 - GLUTAMATE RECEPTOR, IONOTROPIC, KAINATE 3; GRIK3 - OMIM

 
 
* 138243

GLUTAMATE RECEPTOR, IONOTROPIC, KAINATE 3; GRIK3


Alternative titles; symbols

GLUTAMATE RECEPTOR 7; GLUR7; GLR7


HGNC Approved Gene Symbol: GRIK3

Cytogenetic location: 1p34.3     Genomic coordinates (GRCh38): 1:36,795,527-37,034,515 (from NCBI)


TEXT

▼ Cloning and Expression

Synapses using L-glutamate are the principal excitatory synapses of the vertebrate nervous system. Puranam et al. (1993) isolated a human glutamate receptor subunit 7 cosmid after high stringency screening of a human genomic placental library using a rat GLUR7 cDNA as a probe. Based on its homology to rat GLUR7, the human gene product was classified as a kainate subtype.


▼ Mapping

By somatic cell hybrid analysis, Puranam et al. (1993) mapped the GLUR7 gene to chromosome 1. By fluorescence in situ hybridization, the gene was regionalized to 1p34-p33.


▼ REFERENCES

  1. Puranam, R. S., Eubanks, J. H., Heinemann, S. F., McNamara, J. O. Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Molec. Genet. 19: 581-588, 1993. [PubMed: 8128318, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/6/1994
Edit History:
carol : 06/25/2014
dkim : 11/13/1998
carol : 10/10/1994
jason : 6/6/1994

* 138243

GLUTAMATE RECEPTOR, IONOTROPIC, KAINATE 3; GRIK3


Alternative titles; symbols

GLUTAMATE RECEPTOR 7; GLUR7; GLR7


HGNC Approved Gene Symbol: GRIK3

Cytogenetic location: 1p34.3     Genomic coordinates (GRCh38): 1:36,795,527-37,034,515 (from NCBI)


TEXT

Cloning and Expression

Synapses using L-glutamate are the principal excitatory synapses of the vertebrate nervous system. Puranam et al. (1993) isolated a human glutamate receptor subunit 7 cosmid after high stringency screening of a human genomic placental library using a rat GLUR7 cDNA as a probe. Based on its homology to rat GLUR7, the human gene product was classified as a kainate subtype.


Mapping

By somatic cell hybrid analysis, Puranam et al. (1993) mapped the GLUR7 gene to chromosome 1. By fluorescence in situ hybridization, the gene was regionalized to 1p34-p33.


REFERENCES

  1. Puranam, R. S., Eubanks, J. H., Heinemann, S. F., McNamara, J. O. Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Molec. Genet. 19: 581-588, 1993. [PubMed: 8128318] [Full Text: https://doi.org/10.1007/BF01233385]


Creation Date:
Victor A. McKusick : 6/6/1994

Edit History:
carol : 06/25/2014
dkim : 11/13/1998
carol : 10/10/1994
jason : 6/6/1994



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 6, 2024