Alternative titles; symbols
HGNC Approved Gene Symbol: GSTM4
Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,656,099-109,667,727 (from NCBI)
The glutathione S-transferases (GST; EC 2.5.1.18) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens (Mannervik, 1985). See GSTM1 (138350) for additional background.
Ross and Board (1993) cloned and characterized GSTM4. Ross et al. (1993) reported that a probe derived from GSTM4 cross-hybridized with the other 3 known human mu class GST genes: GSTM1, GSTM2 (138380), and GSTM3 (138390).
Comstock et al. (1993) reported the complete cDNA and gene sequence of GSTM4. The deduced amino acid sequence of GSTM4 was 87%, 83%, and 70% identical to GSTM1, GSTM2, and GSTM3 sequences, respectively.
Using PCR amplification of a unique region of the GSTM4 gene from a panel of rodent-human somatic cell hybrid DNAs, Comstock et al. (1993) determined that the GSTM4 gene is located on chromosome 1.
By in situ hybridization, Ross et al. (1993) mapped the GSTM4 gene to chromosome 1p13. Taylor et al. (1991) had found that GSTM4 and GSTM2 were located in the same cosmid.
Comstock, K. E., Johnson, K. J., Rifenbery, D., Henner, W. D. Isolation and analysis of the gene and cDNA for a human mu class glutathione S-transferase, GSTM4. J. Biol. Chem. 268: 16958-16965, 1993. [PubMed: 8349586]
Mannervik, B. The isozymes of glutathione transferase. Adv. Enzymol. Relat. Areas Molec. Biol. 57: 357-417, 1985. [PubMed: 3898742] [Full Text: https://doi.org/10.1002/9780470123034.ch5]
Ross, V. L., Board, P. G., Webb, G. C. Chromosomal mapping of the human mu class glutathione S-transferases to 1p13. Genomics 18: 87-91, 1993. [PubMed: 8276420] [Full Text: https://doi.org/10.1006/geno.1993.1429]
Ross, V. L., Board, P. G. Molecular cloning and heterologous expression of an alternatively spliced human mu class glutathione S-transferase transcript. Biochem. J. 294: 373-380, 1993. [PubMed: 8373352] [Full Text: https://doi.org/10.1042/bj2940373]
Taylor, J. B., Oliver, J., Sherrington, R., Pemble, S. E. Structure of human glutathione S-transferase class mu genes. Biochem. J. 274: 587-593, 1991. [PubMed: 2006920] [Full Text: https://doi.org/10.1042/bj2740587]