Entry - 139280 - GUANYLATE KINASE 2; GUK2 - OMIM

 
 
139280

GUANYLATE KINASE 2; GUK2


HGNC Approved Gene Symbol: GUK2

Cytogenetic location: 1q32.1-q42     Genomic coordinates (GRCh38): 1:198,700,001-236,400,000


▼ TEXT

From study of human-Chinese hamster hybrids, Meera Khan et al. (1974) concluded that 2 guanylate kinase components, GUK1 (139270) and GUK2, demonstrated electrophoretically, are determined by separate loci on chromosome 1 distal to q22. GUK3 (139290) is also believed to be determined by a separate locus. Monn and Christiansen (1972) screened 385 persons in a systematic search for genetically determined variants in man, but in vain.


▼ REFERENCES

  1. Meera Khan, P., Los, W. R. T., Pearson, P. L., Westerveld, A., Bootsma, D. Genetical studies on the multiple forms of human guanylate kinase in man-Chinese hamster somatic cell hybrids. Hum. Hered. 24: 415-423, 1974. [PubMed: 4377261, related citations] [Full Text]

  2. Monn, E., Christiansen, R. O. Guanylate kinase in man--multiple molecular forms. Hum. Hered. 22: 18-27, 1972. [PubMed: 5036631, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/4/1986
Edit History:
psherman : 04/15/1998
alopez : 9/25/1997
alopez : 9/8/1997
terry : 7/28/1997
carol : 7/22/1993
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988
reenie : 6/4/1986

139280

GUANYLATE KINASE 2; GUK2


HGNC Approved Gene Symbol: GUK2

Cytogenetic location: 1q32.1-q42     Genomic coordinates (GRCh38): 1:198,700,001-236,400,000


TEXT

From study of human-Chinese hamster hybrids, Meera Khan et al. (1974) concluded that 2 guanylate kinase components, GUK1 (139270) and GUK2, demonstrated electrophoretically, are determined by separate loci on chromosome 1 distal to q22. GUK3 (139290) is also believed to be determined by a separate locus. Monn and Christiansen (1972) screened 385 persons in a systematic search for genetically determined variants in man, but in vain.


REFERENCES

  1. Meera Khan, P., Los, W. R. T., Pearson, P. L., Westerveld, A., Bootsma, D. Genetical studies on the multiple forms of human guanylate kinase in man-Chinese hamster somatic cell hybrids. Hum. Hered. 24: 415-423, 1974. [PubMed: 4377261] [Full Text: https://doi.org/10.1159/000152700]

  2. Monn, E., Christiansen, R. O. Guanylate kinase in man--multiple molecular forms. Hum. Hered. 22: 18-27, 1972. [PubMed: 5036631] [Full Text: https://doi.org/10.1159/000152463]


Creation Date:
Victor A. McKusick : 6/4/1986

Edit History:
psherman : 04/15/1998
alopez : 9/25/1997
alopez : 9/8/1997
terry : 7/28/1997
carol : 7/22/1993
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988
reenie : 6/4/1986



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 25, 2024