Alternative titles; symbols
HGNC Approved Gene Symbol: H1-3
Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,234,212-26,234,987 (from NCBI)
For background information on histones, histone gene clusters, and the H1 histone family, see HIST1H1A (142709).
Albig et al. (1991) identified a gene encoding a member of the H1 class of histones and designated it H1.3.
See HIST1H1A (142709) for functional information on H1 histones.
By in situ hybridization, Tanguay et al. (1987) mapped the histone H1.3 gene to chromosome 6p12-q21.
By PCR analysis of chromosomal DNA from a panel of human/rodent somatic cell hybrids and by fluorescence in situ hybridization, Albig et al. (1993) demonstrated that 6 human H1 histone genes, including H1.3, are located on chromosome 6p22.2-p21.1. By analysis of a YAC contig, Albig et al. (1997) mapped the H1.3 gene to chromosome 6p21.3 within a cluster of 35 histone genes, including H1.1 (HIST1H1A; 142709) to H1.4 (HIST1H1E; 142220) and H1T (HIST1H1T; 142712). The H1.5 gene (HIST1H1B; 142711) is part of a separate subcluster within the same chromosomal region.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H1D.
Albig, W., Drabent, B., Kunz, J., Kalff-Suske, M., Grzeschik, K.-H., Doenecke, D. All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. Genomics 16: 649-654, 1993. [PubMed: 8325638] [Full Text: https://doi.org/10.1006/geno.1993.1243]
Albig, W., Kardalinou, E., Drabent, B., Zimmer, A., Doenecke, D. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Genomics 10: 940-948, 1991. [PubMed: 1916825] [Full Text: https://doi.org/10.1016/0888-7543(91)90183-f]
Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966]
Tanguay, R. M., Berube, D., Gagne, R. Localization of histone genes to chromosomes 6, 12, and 1 by in situ hybridization. (Abstract) Cytogenet. Cell Genet. 46: 702 only, 1987.