Alternative titles; symbols
HGNC Approved Gene Symbol: H1-5
Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,866,792-27,867,588 (from NCBI)
For background information on histones, histone gene clusters, and the H1 histone family, see HIST1H1A (142709).
Albig et al. (1997) isolated the gene for H1.5 histone.
By investigating MSX1 (142983) function in repression of myogenic gene expression, Lee et al. (2004) identified a physical interaction between MSX1 and H1B. Lee et al. (2004) found that MSX1 and H1B bind to a key regulatory element of MYOD (159970), a central regulator of skeletal muscle differentiation, where they induce repressed chromatin. Moreover, MSX1 and H1B cooperated to inhibit muscle differentiation in cell culture and in Xenopus animal caps. Lee et al. (2004) concluded that their findings defined a theretofore unknown function for linker histones in gene-specific transcriptional regulation.
See HIST1H1A (142709) for additional functional information on H1 histones.
By PCR analysis of chromosomal DNA from a panel of human/rodent somatic cell hybrids, Albig et al. (1993) found that 6 human H1 histone genes, including H1.5, are located on chromosome 6. By fluorescence in situ hybridization with human metaphase chromosomes and PCR analysis of somatic cell hybrid DNAs carrying only fragments of chromosome 6, they demonstrated that the histone genes are clustered in the 6p22.2-p21.1 region.
Albig et al. (1997) showed that there are 2 clusters of histone genes on chromosome 6p. The H1.5 gene is located in the second cluster, about 2 Mb centromeric of the major cluster. In a contig of the histone gene-containing cosmids from this region, Albig and Doenecke (1997) found 1 H1 gene (H1.5), 5 H2A genes, 4 H2B genes, 1 H2B pseudogene, 3 H3 genes, 3 H4 genes, and 1 H4 pseudogene. The cluster extends about 80 kb with a nonordered arrangement of the histone genes. The dinucleotide repeat polymorphic marker D6S105 was localized at the telomeric end of this histone gene cluster. Almost all human histone genes isolated to that time had been localized within the 2 clusters on 6p or in a small group of histone genes on chromosome 1.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H1B.
Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656] [Full Text: https://doi.org/10.1007/s004390050630]
Albig, W., Drabent, B., Kunz, J., Kalff-Suske, M., Grzeschik, K.-H., Doenecke, D. All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. Genomics 16: 649-654, 1993. [PubMed: 8325638] [Full Text: https://doi.org/10.1006/geno.1993.1243]
Albig, W., Meergans, T., Doenecke, D. Characterization of the H1.5 gene completes the set of human H1 subtype genes. Gene 184: 141-148, 1997. [PubMed: 9031620] [Full Text: https://doi.org/10.1016/s0378-1119(96)00582-3]
Lee, H., Habas, R., Abate-Shen, C. Msx1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science 304: 1675-1678, 2004. [PubMed: 15192231] [Full Text: https://doi.org/10.1126/science.1098096]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]