Alternative titles; symbols
HGNC Approved Gene Symbol: H1-6
Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,107,412-26,108,135 (from NCBI)
For background information on histones, histone gene clusters, and the H1 histone family, see HIST1H1A (142709).
Drabent et al. (1991) studied the structure and expression of H1T, the gene for testis-specific histone H1.
Deng et al. (1994) found that the rat H1t locus cosegregated with blood pressure in an F2 population derived from a cross of the Dahl salt-sensitive strain and the Lewis strain. Thus, H1t in rat is a quantitative trait locus for blood pressure.
See HIST1H1A (142709) for additional functional information on H1 histones.
By study of somatic cell hybrids and by in situ hybridization, Albig et al. (1993) demonstrated that the H1T gene is located in a cluster with 5 other H1 histone genes on chromosome 6p22.2-p21.1. By analysis of a YAC contig, Albig et al. (1997) mapped the H1FT gene to chromosome 6p21.3 within a cluster of 35 histone genes, including H1.1 (HIST1H1A; 142709) to H1.4 (HIST1H1E; 142220). The H1.5 gene (HIST1H1B; 142711) is part of a separate subcluster within the same chromosomal region.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H1T.
Deng et al. (1994) reported that the rat testis-specific H1 histone gene maps to chromosome 17,
Albig, W., Drabent, B., Kunz, J., Kalff-Suske, M., Grzeschik, K.-H., Doenecke, D. All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. Genomics 16: 649-654, 1993. [PubMed: 8325638] [Full Text: https://doi.org/10.1006/geno.1993.1243]
Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]
Deng, A. Y., Dene, H., Pravenec, M., Rapp, J. P. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J. Clin. Invest. 93: 2701-2709, 1994. [PubMed: 8201007] [Full Text: https://doi.org/10.1172/JCI117284]
Drabent, B., Kardalinou, E., Doenecke, D. Structure and expression of the human gene encoding testicular H1 histone (H1t). Gene 103: 263-268, 1991. [PubMed: 1889752] [Full Text: https://doi.org/10.1016/0378-1119(91)90284-i]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]