Alternative titles; symbols
HGNC Approved Gene Symbol: EVX2
Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,077,472-176,083,962 (from NCBI)
Using the Drosophila even-skipped (eve) homeobox as a probe, Bastian and Gruss (1990) isolated 2 mouse genes containing an eve-type homeobox, Evx1 (142996) and Evx2. The Evx1 expression pattern during mouse embryogenesis was considered consistent with a role in establishing the anterioposterior embryonic axis.
D'Esposito et al. (1991) identified the human EVX2 gene, containing a homeobox homologous to the Drosophila eve homeobox identified by Macdonald et al. (1986).
D'Esposito et al. (1991) identified the Evx2-type of homeobox on human chromosome 2, 13 kb upstream from HOX4I (142989). That the EVX2 sequences belong to an active gene was indicated by the fact that they are transcribed and properly processed in cells and tissues. In all, 9 homeoboxes are included in a 100-kb region of DNA on the long arm of human chromosome 2.
Bastian et al. (1992) demonstrated that the murine 'even-skipped-like' gene Evx2 is closely linked to the Hox4 complex in that species also, but is transcribed in the opposite direction.
Bastian, H., Gruss, P. A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner. EMBO J. 9: 1839-1852, 1990. Note: Erratum: EMBO J. 10: 3978 only, 1991. [PubMed: 1971786] [Full Text: https://doi.org/10.1002/j.1460-2075.1990.tb08309.x]
Bastian, H., Gruss, P., Duboule, D., Izpisua-Belmonte, J.-C. The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction. Mammalian Genome 3: 241-243, 1992. [PubMed: 1611218] [Full Text: https://doi.org/10.1007/BF00355726]
D'Esposito, M., Morelli, F., Acampora, D., Migliaccio, E., Simeone, A., Boncinelli, E. EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5-prime end of HOX4 locus on chromosome 2. Genomics 10: 43-50, 1991. [PubMed: 1675198] [Full Text: https://doi.org/10.1016/0888-7543(91)90482-t]
Macdonald, P. M., Ingham, P., Struhl, G. Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box. Cell 47: 721-734, 1986. [PubMed: 2877745] [Full Text: https://doi.org/10.1016/0092-8674(86)90515-5]