Entry - *143024 - GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1; GNL1 - OMIM

 
 
* 143024

GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1; GNL1


Alternative titles; symbols

HSR1 GTP-BINDING PROTEIN; HSR1


HGNC Approved Gene Symbol: GNL1

Cytogenetic location: 6p21.33     Genomic coordinates (GRCh38): 6:30,541,381-30,556,489 (from NCBI)


TEXT

▼ Cloning and Expression

Vernet et al. (1994) cloned HSR1, the human homolog of the mouse Mmr1 gene. HSR1 encodes a deduced 438-amino acid protein with a predicted molecular mass of 43.3 kD. The mouse and human proteins share 93% sequence identity. HSR1 is a putative GTP-binding protein.


▼ Mapping

Vernet et al. (1994) identified the HSR1 gene in the human major histocompatibility complex class I region on chromosome 6p21, less than 2 kb centromeric to HLA-E (143010), in the same transcriptional orientation. HSR1 is telomeric to HLA-B (142830) and HLA-C (142840).


▼ REFERENCES

  1. Vernet, C., Ribouchon, M.-T., Chimini, G., Pontarotti, P. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. Mammalian Genome 5: 100-105, 1994. [PubMed: 8180467, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 4/4/1994
Edit History:
carol : 10/22/2014
carol : 5/19/2014
carol : 7/2/1998
mark : 10/10/1995
carol : 4/4/1994

* 143024

GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1; GNL1


Alternative titles; symbols

HSR1 GTP-BINDING PROTEIN; HSR1


HGNC Approved Gene Symbol: GNL1

Cytogenetic location: 6p21.33     Genomic coordinates (GRCh38): 6:30,541,381-30,556,489 (from NCBI)


TEXT

Cloning and Expression

Vernet et al. (1994) cloned HSR1, the human homolog of the mouse Mmr1 gene. HSR1 encodes a deduced 438-amino acid protein with a predicted molecular mass of 43.3 kD. The mouse and human proteins share 93% sequence identity. HSR1 is a putative GTP-binding protein.


Mapping

Vernet et al. (1994) identified the HSR1 gene in the human major histocompatibility complex class I region on chromosome 6p21, less than 2 kb centromeric to HLA-E (143010), in the same transcriptional orientation. HSR1 is telomeric to HLA-B (142830) and HLA-C (142840).


REFERENCES

  1. Vernet, C., Ribouchon, M.-T., Chimini, G., Pontarotti, P. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region. Mammalian Genome 5: 100-105, 1994. [PubMed: 8180467] [Full Text: https://doi.org/10.1007/BF00292335]


Creation Date:
Victor A. McKusick : 4/4/1994

Edit History:
carol : 10/22/2014
carol : 5/19/2014
carol : 7/2/1998
mark : 10/10/1995
carol : 4/4/1994



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 3, 2024