Alternative titles; symbols
HGNC Approved Gene Symbol: IFIT2
Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,302,046-89,309,271 (from NCBI)
For background information on the activity of interferon-induced proteins, see 604456.
Using cloned probes on Southern blots of DNA from a panel of rodent-human somatic cell hybrids, Wathelet et al. (1988) assigned the IFI54K gene to chromosome 10. Thus it is syntenic with the IFI56K gene (147690).
By in situ hybridization, Lafage et al. (1992) concluded that both the IFI54K and the IFI56K genes are located in the 10q23-q24 region.
Daffis et al. (2010) showed that 2-prime-O methylation of viral RNA did not affect interferon induction in West Nile virus-infected fibroblasts but instead modulated the antiviral effects of interferon-induced proteins with tetratricopeptide repeats (IFIT), which are interferon-stimulated genes implicated in regulation of protein translation. Poxvirus and coronavirus mutants that lacked 2-prime-O methyltransferase activity similarly showed enhanced sensitivity to the antiviral actions of interferon and, specifically, IFIT proteins. Daffis et al. (2010) concluded that the 2-prime-O methylation of the 5-prime cap of viral RNA functions to subvert innate host antiviral responses through escape of IFIT-mediated suppression, and suggested an evolutionary explanation for 2-prime-O methylation of cellular mRNA: to distinguish self from non-self RNA. Differential methylation of cytoplasmic RNA probably serves as an example for pattern recognition and restriction of propagation of foreign viral RNA in host cells.
Daffis, S., Szretter, K. J., Schriewer, J., Li, J., Youn, S., Errett, J., Lin, T.-Y., Schneller, S., Zust, R., Dong, H., Thiel, V., Sen, G. C., Fensterl, V., Klimstra, W. B., Pierson, T. C., Buller, R. M., Gale, M., Jr., Shi, P.-Y., Diamond, M. S. 2-prime-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 468: 452-456, 2010. [PubMed: 21085181] [Full Text: https://doi.org/10.1038/nature09489]
Lafage, M., Clauss, I., Couez, D., Simonetti, J., Wathelet, M. G., Huez, G. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. Genomics 13: 458-460, 1992. [PubMed: 1377167] [Full Text: https://doi.org/10.1016/0888-7543(92)90272-t]
Wathelet, M. G., Szpirer, J., Nols, C. B., Clauss, I. M., De Wit, L., Islam, M. Q., Levan, G., Horisberger, M. A., Content, J., Szpirer, C., Huez, G. A. Cloning and chromosomal location of human genes inducible by type I interferon. Somat. Cell Molec. Genet. 14: 415-426, 1988. [PubMed: 3175763] [Full Text: https://doi.org/10.1007/BF01534709]