Entry - *147830 - T-CELL TUMOR INVASION AND METASTASIS 1; TTIM1 - OMIM

 
 
* 147830

T-CELL TUMOR INVASION AND METASTASIS 1; TTIM1


Alternative titles; symbols

INVASION AND METASTASIS FACTORS ON CHROMOSOME 7; INM7
INVASION-INDUCING LOCUS


Cytogenetic location: 7p12-cen     Genomic coordinates (GRCh38): 7:45,400,001-60,100,001


TEXT

▼ Description

The TTIM1 gene is involved in the induction of invasive and metastatic potential in interspecies T-cell hybrids (summary by Habets et al., 1992).


▼ Gene Function

Collard et al. (1987) presented evidence for the existence of genes controlling invasion and metastasis of malignant tumors. Their evidence came from somatic cell fusion studies. Noninvasive, nonmetastatic mouse T-lymphoma cells were fused with invasive human T cells. The human cells were either activated normal peripheral blood lymphocytes or leukemic T lymphoblasts. Both fusions resulted in highly invasive human-mouse T-cell hybrids which metastasized in nude mice. By continued in vitro selection for invasive cells, Collard et al. (1987) were able to isolate invasive hybrids that had lost all human chromosomes except chromosome 7. Collard et al. (1987) presented other evidence that human chromosome 7 is involved in invasive and metastatic characteristics of neoplasms. See also Collard et al. (1988, 1989).


▼ Mapping

To sublocalize the invasion-inducing locus on chromosome 7, Habets et al. (1992) generated hybrids containing only specific regions of human chromosome 7 with or without a small fragment of human chromosome 21. Analysis of these hybrids demonstrated that the invasion-inducing locus, TTIM1, resides on 7p12-cen. Habets et al. (1992) sublocalized other genes on chromosome 7: ARAF2 to 7p12-cen, ACTB (102630) to 7p15-p12, EGFR (131550) to 7p12, MDH2 (154100) to 7cen-q22, and PDGFA (173430) to 7pter-p15.


▼ REFERENCES

  1. Collard, J. G., Habets, G. G. M., van der Kammen, R., Scholtes, E. Genetic basis of T-lymphoma invasion. Invasion Metastasis 9: 379-390, 1989. [PubMed: 2689385, related citations]

  2. Collard, J. G., Roos, E., La Riviere, G., Habets, G. G. M. Genetic analysis of invasion and metastasis. Cancer Surv. 7: 691-710, 1988. [PubMed: 3072071, related citations]

  3. Collard, J. G., van de Poll, M., Scheffer, A., Roos, E., Hopman, A. H. M., Geurts van Kessel, A. H. M., van Dongen, J. J. M. Location of genes involved in invasion and metastasis on human chromosome 7. Cancer Res. 47: 6666-6670, 1987. [PubMed: 3499980, related citations]

  4. Habets, G. G. M., van der Kammen, R. A., Willemsen, V., Balemans, M., Wiegant, J., Collard, J. G. Sublocalization of an invasion-inducing locus and other genes on human chromosome 7. Cytogenet. Cell Genet. 60: 200-205, 1992. [PubMed: 1505215, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 9/22/1987
Edit History:
carol : 10/22/2014
mgross : 10/7/2013
mgross : 10/7/2013
dkim : 9/9/1998
carol : 7/9/1993
carol : 7/1/1993
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
root : 6/27/1988

* 147830

T-CELL TUMOR INVASION AND METASTASIS 1; TTIM1


Alternative titles; symbols

INVASION AND METASTASIS FACTORS ON CHROMOSOME 7; INM7
INVASION-INDUCING LOCUS


Cytogenetic location: 7p12-cen     Genomic coordinates (GRCh38): 7:45,400,001-60,100,001


TEXT

Description

The TTIM1 gene is involved in the induction of invasive and metastatic potential in interspecies T-cell hybrids (summary by Habets et al., 1992).


Gene Function

Collard et al. (1987) presented evidence for the existence of genes controlling invasion and metastasis of malignant tumors. Their evidence came from somatic cell fusion studies. Noninvasive, nonmetastatic mouse T-lymphoma cells were fused with invasive human T cells. The human cells were either activated normal peripheral blood lymphocytes or leukemic T lymphoblasts. Both fusions resulted in highly invasive human-mouse T-cell hybrids which metastasized in nude mice. By continued in vitro selection for invasive cells, Collard et al. (1987) were able to isolate invasive hybrids that had lost all human chromosomes except chromosome 7. Collard et al. (1987) presented other evidence that human chromosome 7 is involved in invasive and metastatic characteristics of neoplasms. See also Collard et al. (1988, 1989).


Mapping

To sublocalize the invasion-inducing locus on chromosome 7, Habets et al. (1992) generated hybrids containing only specific regions of human chromosome 7 with or without a small fragment of human chromosome 21. Analysis of these hybrids demonstrated that the invasion-inducing locus, TTIM1, resides on 7p12-cen. Habets et al. (1992) sublocalized other genes on chromosome 7: ARAF2 to 7p12-cen, ACTB (102630) to 7p15-p12, EGFR (131550) to 7p12, MDH2 (154100) to 7cen-q22, and PDGFA (173430) to 7pter-p15.


REFERENCES

  1. Collard, J. G., Habets, G. G. M., van der Kammen, R., Scholtes, E. Genetic basis of T-lymphoma invasion. Invasion Metastasis 9: 379-390, 1989. [PubMed: 2689385]

  2. Collard, J. G., Roos, E., La Riviere, G., Habets, G. G. M. Genetic analysis of invasion and metastasis. Cancer Surv. 7: 691-710, 1988. [PubMed: 3072071]

  3. Collard, J. G., van de Poll, M., Scheffer, A., Roos, E., Hopman, A. H. M., Geurts van Kessel, A. H. M., van Dongen, J. J. M. Location of genes involved in invasion and metastasis on human chromosome 7. Cancer Res. 47: 6666-6670, 1987. [PubMed: 3499980]

  4. Habets, G. G. M., van der Kammen, R. A., Willemsen, V., Balemans, M., Wiegant, J., Collard, J. G. Sublocalization of an invasion-inducing locus and other genes on human chromosome 7. Cytogenet. Cell Genet. 60: 200-205, 1992. [PubMed: 1505215] [Full Text: https://doi.org/10.1159/000133336]


Creation Date:
Victor A. McKusick : 9/22/1987

Edit History:
carol : 10/22/2014
mgross : 10/7/2013
mgross : 10/7/2013
dkim : 9/9/1998
carol : 7/9/1993
carol : 7/1/1993
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
root : 6/27/1988



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 7, 2024