Alternative titles; symbols
HGNC Approved Gene Symbol: MT1B
Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,651,886-56,653,204 (from NCBI)
Heguy et al. (1986) could detect high levels of MT1B expression only in human hepatoma and renal carcinoma cell lines. They found that the 5-prime flanking region of the gene is highly methylated in nonexpressing cell types but is not methylated in an expressing hepatoma cell line, suggesting to them that tissue expression specificity of MT1B is controlled by a cis-acting mechanism involving methylation of the gene's 5-prime regulatory sequences.
Heguy et al. (1986) determined that the MT1B gene is composed of 3 exons.
Karin et al. (1984), West et al. (1990), and others have mapped the locus containing the MT1 gene family to chromosome 16q13.
Heguy, A., West, A., Richards, R. I., Karin, M. Structure and tissue-specific expression of the human metallothionein IB gene. Molec. Cell. Biol. 6: 2149-2157, 1986. [PubMed: 3785191] [Full Text: https://doi.org/10.1128/mcb.6.6.2149-2157.1986]
Karin, M., Eddy, R. L., Henry, W. M., Haley, L. L., Byers, M. G., Shows, T. B. Human metallothionein genes are clustered on chromosome 16. Proc. Nat. Acad. Sci. 81: 5494-5498, 1984. [PubMed: 6089206] [Full Text: https://doi.org/10.1073/pnas.81.17.5494]
West, A. K., Stallings, R., Hildebrand, C. E., Chiu, R., Karin, M., Richards, R. I. Human metallothionein genes: structure of the functional locus at 16q13. Genomics 8: 513-518, 1990. [PubMed: 2286373] [Full Text: https://doi.org/10.1016/0888-7543(90)90038-v]