Alternative titles; symbols
HGNC Approved Gene Symbol: PSMD7
Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:74,296,814-74,306,288 (from NCBI)
Gridley et al. (1990) stated that the Mov34 mutation is a recessive embryonic lethal mutation caused by retroviral integration into the murine germline. This integration disrupts a transcription unit, designated Mov34, that appears to encode a novel protein. Gridley et al. (1990) found that the Mov34 transcript is conserved in evolution. A Drosophila homolog encodes a protein with 62% amino acid identity to the murine protein.
Gridley et al. (1991) cloned a full-length cDNA encoding mouse Mov34. The deduced 321-amino acid protein has a calculated molecular mass of 36 kD.
Gridley et al. (1990) found that the Mov34 gene is located on mouse chromosome 8. By Southern analysis of rodent/human cell hybrids and by in situ hybridization, they mapped the human homolog of Mov34 to chromosome 16q23-q24. An evolutionarily conserved syntenic relationship exists between these 2 regions. Mouse chromosome 8 also contains 'oligosyndactyly' (os), another recessive lethal mutation. By genetic studies, Gridley et al. (1990) ruled out the possibility that os resides at the same locus as the Mov34 integration.
Gridley, T., Gray, D. A., Orr-Weaver, T., Soriano, P., Barton, D. E., Francke, U., Jaenisch, R. Molecular analysis of the Mov34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila. Development 109: 235-242, 1990. [PubMed: 2209467] [Full Text: https://doi.org/10.1242/dev.109.1.235]
Gridley, T., Jaenisch, R., Gendron-Maguire, M. The murine Mov-34 gene: full-length cDNA and genomic organization. Genomics 11: 501-507, 1991. [PubMed: 1837787] [Full Text: https://doi.org/10.1016/0888-7543(91)90056-k]