HGNC Approved Gene Symbol: MUC4
Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,746,771-195,811,929 (from NCBI)
From a lambda-gt11 cDNA library constructed from human tracheobronchial mucosa, Porchet et al. (1991) isolated a partial cDNA clone that reacted with a polyclonal antiserum raised to chemically deglycosylated pronase glycopeptides from human bronchial mucins. The novel tracheobronchial mucin gene was referred to as mucin 4.
Using real-time RT-PCR, Moehle et al. (2006) found that MUC4 was highly expressed in adult trachea and colon, and in fetal lung. Expression was moderate in adult testis, prostate, mammary gland, lung and stomach, and weak in spinal cord, thymus, and salivary gland. No expression was detected in other tissues examined.
Porchet et al. (1991) mapped the MUC4 gene to chromosome 3 by analysis of somatic cell hybrids. By in situ hybridization, Van Cong et al. (1991) mapped MUC4 to 3q29. They also demonstrated a VNTR polymorphism useful for family linkage studies. The full report was given by Gross et al. (1992). (Note that Nguyen Van Cong's name is sometimes published as Nguyen, V. C. rather than Van Cong, N. Nguyen is indeed the surname.)
Gross, M.-S., Guyonnet-Duperat, V., Porchet, N., Bernheim, A., Aubert, J. P., Nguyen, V. C. Mucin 4 (MUC4) gene: regional assignment (3q29) and RFLP analysis. Ann. Genet. 35: 21-26, 1992. [PubMed: 1351710]
Moehle, C., Ackermann, N., Langmann, T., Aslanidis, C., Kel, A., Kel-Margoulis, O., Schmitz-Madry, A., Zahn, A., Stremmel, W., Schmitz, G. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Molec. Med. 84: 1055-1066, 2006. [PubMed: 17058067] [Full Text: https://doi.org/10.1007/s00109-006-0100-2]
Porchet, N., Nguyen, V. C., Dufosse, J., Audie, J. P., Guyonnet-Duperat, V., Gross, M. S., Denis, C., Degand, P., Bernheim, A., Aubert, J. P. Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem. Biophys. Res. Commun. 175: 414-422, 1991. [PubMed: 1673336] [Full Text: https://doi.org/10.1016/0006-291x(91)91580-6]
Van Cong, N., Aubert, J.-P., Gross, M.-S., Porchet, N., Degand, P., Bernheim, A. Tracheobronchial mucin 4 (MUC4) gene: assignment to 3q29 and polymorphism of VNTR type. (Abstract) Cytogenet. Cell Genet. 58: 1879-1880, 1991.