HGNC Approved Gene Symbol: MNDA
Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,831,351-158,849,502 (from NCBI)
Briggs et al. (1992) cloned a human cDNA encoding the myeloid cell nuclear differentiation antigen (MNDA), a deduced 406-amino acid protein that is expressed specifically in granulocytes, monocytes, and earlier stage cells of these lineages. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. In its pattern of expression and/or regulation, MNDA resembles IFI16 (147586), suggesting that these genes participate in blood cell-specific responses to interferons (Briggs et al., 1992; Briggs et al., 1994).
Briggs et al. (1994) localized the MNDA gene, which is present in single copy, to chromosome 1q21-q22 by study of rodent/human hybrid cell lines followed by pulsed field gel electrophoresis. They found that MNDA is located within 2,200 kb of FCER1A (147140), APCS (104770), CRP (123260), and SPTA1 (182860).
Briggs, J. A., Burrus, G. R., Stickney, B. D., Brigs, R. C. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. J. Cell. Biochem. 49: 82-92, 1992. [PubMed: 1644857] [Full Text: https://doi.org/10.1002/jcb.240490114]
Briggs, R. C., Briggs, J. A., Ozer, J., Sealy, L., Dworkin, L. L., Kingsmore, S. F., Seldin, M. F., Kaur, G. P., Athwal, R. S., Dessypris, E. N. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. Blood 83: 2153-2162, 1994. [PubMed: 7512843]