Entry - *165110 - S13 AVIAN ERYTHROBLASTOSIS ONCOGENE HOMOLOG; SEA - OMIM

 
 
* 165110

S13 AVIAN ERYTHROBLASTOSIS ONCOGENE HOMOLOG; SEA


Alternative titles; symbols

ONCOGENE SEA


HGNC Approved Gene Symbol: SEA

Cytogenetic location: 11q13     Genomic coordinates (GRCh38): 11:63,600,001-77,400,000


TEXT

▼ Cloning and Expression

Smith et al. (1989) cloned and sequenced the oncogene of the avian erythroblastosis virus S13. The oncogene, designated v-sea, was found to be a member of the protein-tyrosine gene family. It was fused in frame with the retrovirus S13 envelope (env) gene, thus generating a fusion protein with a structure resembling that of a growth factor receptor.


▼ Mapping

Williams et al. (1987, 1988) assigned the human homolog of the transforming gene SEA from S13 avian erythroblastosis virus to chromosome 11 by Southern blot analysis of cDNAs from a panel of human-rodent somatic cell hybrids. By in situ hybridization, the assignment was refined to 11q13. Two other putative oncogenes, INT2 (164950) and BCL1 (168461), also map to 11q13.

Richard et al. (1991) described a high resolution radiation hybrid map of 11q12-q13, which placed SEA between PYGM (608455) and KRN1 (148021).

Rochelle et al. (1992) indicated that the corresponding murine locus is on proximal chromosome 19.


▼ REFERENCES

  1. Richard, C. W., Withers, D. A., Meeker, T. C., Myers, R. M. A radiation hybrid map of the proximal long arm of human chromosome 11 containing the MEN-1 and bcl-1 disease locus. (Abstract) Cytogenet. Cell Genet. 58: 1970 only, 1991.

  2. Rochelle, J. M., Watson, M. L., Oakey, R. J., Seldin, M. F. A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics 14: 26-31, 1992. [PubMed: 1358795, related citations] [Full Text]

  3. Smith, D. R., Vogt, P. K., Hayman, M. J. The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family. Proc. Nat. Acad. Sci. 86: 5291-5295, 1989. [PubMed: 2546151, related citations] [Full Text]

  4. Williams, B. P., Goodfellow, P. N., Shipley, J. M., Spurr, N. K., Smith, D. R., Hayman, M. J. Assignment of SEA, a putative human oncogene, to chromosome 11q13. (Abstract) Cytogenet. Cell Genet. 46: 717 only, 1987.

  5. Williams, B. P., Shipley, J. P., Spurr, N. K., Smith, D. R., Hayman, M. J., Goodfellow, P. N. A human sequence homologous to v-sea maps to chromosome 11, band q13. Oncogene 3: 345-348, 1988. [PubMed: 3205567, related citations]


Creation Date:
Victor A. McKusick : 9/22/1987
Edit History:
carol : 10/22/2014
carol : 2/9/2011
alopez : 7/9/2010
carol : 3/9/2004
carol : 12/6/2001
terry : 8/5/1997
mark : 6/10/1996
carol : 9/22/1992
supermim : 3/16/1992
carol : 2/22/1992
carol : 9/19/1991
supermim : 3/20/1990
ddp : 10/27/1989

* 165110

S13 AVIAN ERYTHROBLASTOSIS ONCOGENE HOMOLOG; SEA


Alternative titles; symbols

ONCOGENE SEA


HGNC Approved Gene Symbol: SEA

Cytogenetic location: 11q13     Genomic coordinates (GRCh38): 11:63,600,001-77,400,000


TEXT

Cloning and Expression

Smith et al. (1989) cloned and sequenced the oncogene of the avian erythroblastosis virus S13. The oncogene, designated v-sea, was found to be a member of the protein-tyrosine gene family. It was fused in frame with the retrovirus S13 envelope (env) gene, thus generating a fusion protein with a structure resembling that of a growth factor receptor.


Mapping

Williams et al. (1987, 1988) assigned the human homolog of the transforming gene SEA from S13 avian erythroblastosis virus to chromosome 11 by Southern blot analysis of cDNAs from a panel of human-rodent somatic cell hybrids. By in situ hybridization, the assignment was refined to 11q13. Two other putative oncogenes, INT2 (164950) and BCL1 (168461), also map to 11q13.

Richard et al. (1991) described a high resolution radiation hybrid map of 11q12-q13, which placed SEA between PYGM (608455) and KRN1 (148021).

Rochelle et al. (1992) indicated that the corresponding murine locus is on proximal chromosome 19.


REFERENCES

  1. Richard, C. W., Withers, D. A., Meeker, T. C., Myers, R. M. A radiation hybrid map of the proximal long arm of human chromosome 11 containing the MEN-1 and bcl-1 disease locus. (Abstract) Cytogenet. Cell Genet. 58: 1970 only, 1991.

  2. Rochelle, J. M., Watson, M. L., Oakey, R. J., Seldin, M. F. A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics 14: 26-31, 1992. [PubMed: 1358795] [Full Text: https://doi.org/10.1016/s0888-7543(05)80278-2]

  3. Smith, D. R., Vogt, P. K., Hayman, M. J. The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family. Proc. Nat. Acad. Sci. 86: 5291-5295, 1989. [PubMed: 2546151] [Full Text: https://doi.org/10.1073/pnas.86.14.5291]

  4. Williams, B. P., Goodfellow, P. N., Shipley, J. M., Spurr, N. K., Smith, D. R., Hayman, M. J. Assignment of SEA, a putative human oncogene, to chromosome 11q13. (Abstract) Cytogenet. Cell Genet. 46: 717 only, 1987.

  5. Williams, B. P., Shipley, J. P., Spurr, N. K., Smith, D. R., Hayman, M. J., Goodfellow, P. N. A human sequence homologous to v-sea maps to chromosome 11, band q13. Oncogene 3: 345-348, 1988. [PubMed: 3205567]


Creation Date:
Victor A. McKusick : 9/22/1987

Edit History:
carol : 10/22/2014
carol : 2/9/2011
alopez : 7/9/2010
carol : 3/9/2004
carol : 12/6/2001
terry : 8/5/1997
mark : 6/10/1996
carol : 9/22/1992
supermim : 3/16/1992
carol : 2/22/1992
carol : 9/19/1991
supermim : 3/20/1990
ddp : 10/27/1989



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 4, 2024