Entry - *165320 - LIVER CANCER ONCOGENE; LCO - OMIM

 
 
* 165320

LIVER CANCER ONCOGENE; LCO


Alternative titles; symbols

ONCOGENE LCA


Cytogenetic location: 2q14-q21     Genomic coordinates (GRCh38): 2:112,200,001-136,100,000


TEXT

▼ Cloning and Expression

Ochiya et al. (1986) isolated a novel oncogene, which they designated LCA, from a primary human hepatocellular carcinoma by transforming assays using NIH 3T3 cells and a calcium phosphate coprecipitation method.


▼ Mapping

Ochiya et al. (1986) mapped the LCO gene to chromosome 2 by Southern blot analysis of DNA from flow-sorted human chromosomes and from human/mouse somatic hybrid cells. Tokino et al. (1988) regionalized the gene to 2q14-q21 by in situ hybridization.


▼ Nomenclature

The gene symbol proposed by the nomenclature committee of the Human Gene Mapping Workshops was LCO (McAlpine, 1989). (LCA was used as a symbol for 2 other genes: light chain A of clathrin (CLTA; 118960) and leukocyte common antigen (PTPRC; 151460).)

▼ REFERENCES

  1. McAlpine, P. J. Personal Communication. Winnipeg, Manitoba, Canada 1989.

  2. Ochiya, T., Fujiyama, A., Fukushige, S., Hatada, I., Matsubara, K. Molecular cloning of an oncogene from a human hepatocellular carcinoma. Proc. Nat. Acad. Sci. 83: 4993-4997, 1986. [PubMed: 3014525, related citations] [Full Text]

  3. Tokino, T., Satoh, H., Yoshida, M. C., Ochiya, T., Matsubara, K. Regional localization of the LCA oncogene to human chromosome region 2q14-q21. Cytogenet. Cell Genet. 48: 63-64, 1988. [PubMed: 2846240, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 12/30/1988
Edit History:
carol : 01/16/2014
mark : 6/10/1996
mark : 12/4/1995
mimadm : 4/29/1994
warfield : 4/12/1994
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
root : 9/10/1989

* 165320

LIVER CANCER ONCOGENE; LCO


Alternative titles; symbols

ONCOGENE LCA


Cytogenetic location: 2q14-q21     Genomic coordinates (GRCh38): 2:112,200,001-136,100,000


TEXT

Cloning and Expression

Ochiya et al. (1986) isolated a novel oncogene, which they designated LCA, from a primary human hepatocellular carcinoma by transforming assays using NIH 3T3 cells and a calcium phosphate coprecipitation method.


Mapping

Ochiya et al. (1986) mapped the LCO gene to chromosome 2 by Southern blot analysis of DNA from flow-sorted human chromosomes and from human/mouse somatic hybrid cells. Tokino et al. (1988) regionalized the gene to 2q14-q21 by in situ hybridization.


Nomenclature

The gene symbol proposed by the nomenclature committee of the Human Gene Mapping Workshops was LCO (McAlpine, 1989). (LCA was used as a symbol for 2 other genes: light chain A of clathrin (CLTA; 118960) and leukocyte common antigen (PTPRC; 151460).)

REFERENCES

  1. McAlpine, P. J. Personal Communication. Winnipeg, Manitoba, Canada 1989.

  2. Ochiya, T., Fujiyama, A., Fukushige, S., Hatada, I., Matsubara, K. Molecular cloning of an oncogene from a human hepatocellular carcinoma. Proc. Nat. Acad. Sci. 83: 4993-4997, 1986. [PubMed: 3014525] [Full Text: https://doi.org/10.1073/pnas.83.14.4993]

  3. Tokino, T., Satoh, H., Yoshida, M. C., Ochiya, T., Matsubara, K. Regional localization of the LCA oncogene to human chromosome region 2q14-q21. Cytogenet. Cell Genet. 48: 63-64, 1988. [PubMed: 2846240] [Full Text: https://doi.org/10.1159/000132589]


Creation Date:
Victor A. McKusick : 12/30/1988

Edit History:
carol : 01/16/2014
mark : 6/10/1996
mark : 12/4/1995
mimadm : 4/29/1994
warfield : 4/12/1994
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
root : 9/10/1989



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 29, 2024