Entry - 170990 - PEROXIDASE, SALIVARY; SAPX - OMIM

 
 
170990

PEROXIDASE, SALIVARY; SAPX



▼ TEXT

Salivary peroxidase is polymorphic; leukocyte peroxidase is not (Azen, 1977). Azen concluded that homozygosity for a recessive gene determines a phenotype of fast electrophoretic mobility (SAPX-1). SAPX-2 and SAPX-3 phenotypes are each determined by a dominant allele at the locus of the recessive allele. Furthermore, Azen (1977) found precise correlation between acid protein types (Pa; 168730) and peroxidase types. This suggested to him that the peroxidase polymorphism is due not to mutation in its structural gene but to modification of the SAPX-1 gene product by the products of the Pa locus.

Data on gene frequencies of allelic variants were tabulated by Roychoudhury and Nei (1988).

▼ REFERENCES

  1. Azen, E. A. Salivary peroxidase (SAPX): genetic modification and relationship to the proline-rich (Pr) and (Pa) proteins. Biochem. Genet. 15: 9-29, 1977. [PubMed: 849256, related citations] [Full Text]

  2. Roychoudhury, A. K., Nei, M. Human Polymorphic Genes: World Distribution. New York: Oxford Univ. Press (pub.) 1988.


Creation Date:
Victor A. McKusick : 6/2/1986
Edit History:
warfield : 3/4/1994
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
carol : 4/20/1989
marie : 3/25/1988

170990

PEROXIDASE, SALIVARY; SAPX



TEXT

Salivary peroxidase is polymorphic; leukocyte peroxidase is not (Azen, 1977). Azen concluded that homozygosity for a recessive gene determines a phenotype of fast electrophoretic mobility (SAPX-1). SAPX-2 and SAPX-3 phenotypes are each determined by a dominant allele at the locus of the recessive allele. Furthermore, Azen (1977) found precise correlation between acid protein types (Pa; 168730) and peroxidase types. This suggested to him that the peroxidase polymorphism is due not to mutation in its structural gene but to modification of the SAPX-1 gene product by the products of the Pa locus.

Data on gene frequencies of allelic variants were tabulated by Roychoudhury and Nei (1988).

REFERENCES

  1. Azen, E. A. Salivary peroxidase (SAPX): genetic modification and relationship to the proline-rich (Pr) and (Pa) proteins. Biochem. Genet. 15: 9-29, 1977. [PubMed: 849256] [Full Text: https://doi.org/10.1007/BF00484545]

  2. Roychoudhury, A. K., Nei, M. Human Polymorphic Genes: World Distribution. New York: Oxford Univ. Press (pub.) 1988.


Creation Date:
Victor A. McKusick : 6/2/1986

Edit History:
warfield : 3/4/1994
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/27/1989
carol : 4/20/1989
marie : 3/25/1988



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 30, 2024