Alternative titles; symbols
HGNC Approved Gene Symbol: PSMA5
Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,399,042-109,426,448 (from NCBI)
DeMartino et al. (1991) cloned human PSMA5, which they called 'subunit zeta.' The cDNA encoded a deduced 241-amino acid polypeptide. The calculated and observed molecular masses were 26 kD and 29 kD, respectively. Northern blot analysis revealed an mRNA of 1.2 kb in both human placenta and HeLa cells.
Coux et al. (1996) reviewed the structures and functions of the 20S proteasome subunits. The alpha subunits comprise the outer rings of the proteasome. Some alpha subunits contain a functional nuclear localization signal; proteasomes are found in both the nuclear and cytoplasmic compartments of the cell. Alpha subunits may constitute a physical barrier that limits access of cytosolic proteins into the inner proteolytic chamber.
To determine whether the order in a cluster of genes that had been mapped to chromosome 1q in the Chinese hamster by a coamplification mapping technique is conserved in the human genome, Mayau et al. (1998) screened the YAC library from the CEPH laboratory by PCR. They found that, as in the hamster, the PSMA5 gene was close to GNAI3 (139370), which is located at 1p13.
Coux, O., Tanaka, K., Goldberg, A. L. Structure and functions of the 20S and 26S proteasomes. Ann. Rev. Biochem. 65: 801-847, 1996. [PubMed: 8811196] [Full Text: https://doi.org/10.1146/annurev.bi.65.070196.004101]
DeMartino, G. N., Orth, K., McCullough, M. L., Lee, L. W., Munn, T. Z., Moomaw, C. R., Dawson, P. A., Slaughter, C. A. The primary structures of four subunits of the human, high molecular weight proteinase, macropain (proteasome), are distinct but homologous. Biochim. Biophys. Acta 1079: 29-38, 1991. [PubMed: 1888762] [Full Text: https://doi.org/10.1016/0167-4838(91)90020-z]
Mayau, V., Baron, B., Buttin, G., Debatisse, M. Twelve genes, including the unassigned proteasome zeta subunit gene, ordered within the human 1p13 region. Mammalian Genome 9: 331-333, 1998. [PubMed: 9530635] [Full Text: https://doi.org/10.1007/s003359900761]