Alternative titles; symbols
HGNC Approved Gene Symbol: PSMA4
Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,540,405-78,552,417 (from NCBI)
Proteasomes are multicatalytic proteinase complexes consisting of a set of nonidentical polypeptide components, such as PSMA4 (Tamura et al., 1991).
By biochemical analysis and screening a liver cell line cDNA library with rat Psma4, Tamura et al. (1991) isolated a cDNA encoding human PSMA4, which they called HC9. The predicted 261-amino acid protein has a calculated molecular mass of 29.5 kD. HC9 is highly homologous to HC2 (PSMA1; 602854), HC3 (PSMA2; 176842), and HC8 (PSMA3; 176843), particularly in the N-terminal half, and is 99% identical to the rat protein.
Amos et al. (2008) mapped the CHRNA3 (118503), CHRNA5 (118505), CHRNB4 (118509), and PSMA4 genes within a 100-kb region on chromosome 15q25.1.
Amos, C. I., Wu, X., Broderick, P., Gorlov, I. P., Gu, J., Eisen, T., Dong, Q., Zhang, Q., Gu, X., Vijayakrishnan, J., Sullivan, K., Matakidou, A., Wang, Y., Mills, G., Doheny, K., Tsai, Y.-Y., Chen, W. V., Shete, S., Spitz, M. R., Houlston, R. S. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nature Genet. 40: 616-622, 2008. [PubMed: 18385676] [Full Text: https://doi.org/10.1038/ng.109]
Tamura, T., Lee, D. H., Osaka, F., Fujiwara, T., Shin, S., Chung, C. H., Tanaka, K., Ichihara, A. Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). Biochim. Biophys. Acta 1089: 95-102, 1991. [PubMed: 2025653] [Full Text: https://doi.org/10.1016/0167-4781(91)90090-9]