Alternative titles; symbols
HGNC Approved Gene Symbol: PTPN4
Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,759,922-119,984,899 (from NCBI)
By screening human megakaryoblastic cell line and umbilical vein endothelial cell cDNA libraries, Gu et al. (1991) obtained a 3.7-kb cDNA, which they designated PTPase MEG. The predicted protein had an approximate molecular mass of 106 kD. It had no apparent membrane-spanning region and contained a single protein-tyrosine phosphatase domain that was 35 to 40% identical to previously described tyrosine phosphatase domains. The N-terminal region was 45% identical to the N terminus of erythrocyte protein-4.1 (130500), a cytoskeletal protein. The identification of a protein-tyrosine phosphatase that is related to cytoskeletal proteins implies that cell signaling activity resides not only in transmembrane receptors but in cytoskeletal receptors as well.
Gu, M., York, J. D., Warshawsky, I., Majerus, P. W. Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc. Nat. Acad. Sci. 88: 5867-5871, 1991. [PubMed: 1648233] [Full Text: https://doi.org/10.1073/pnas.88.13.5867]