HGNC Approved Gene Symbol: CRABP2
Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,699,606-156,705,784 (from NCBI)
Giguere et al. (1990) isolated a cDNA encoding mouse Crabp2 by a low stringency cloning strategy using a probe from previously cloned Crabp1 cDNA (180230). Giguere et al. (1990) found that Crabp2 is abundantly but transiently expressed during embryogenesis and is predominantly expressed in the skin of the adult mouse. CRABP2 mRNA levels were induced by at least 50-fold in F9 teratocarcinoma cells cultured in the presence of retinoic acid.
MacGregor et al. (1992) determined the genomic organization of the murine Crabp2 gene and performed a detailed analysis of its transcriptional unit. It was shown to be approximately 4.6 kb long and to contain 4 exons in a structure common to other members of the family of serum and cellular retinoid-binding proteins.
Elder et al. (1992) mapped the CRABP2 gene to chromosome 1q21 by fluorescence in situ hybridization. Localization was confirmed by hybridization of a CRABP2 cDNA clone against a human/mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. Flagiello et al. (1997) mapped CRABP2 to 1q21.3 by fluorescence in situ hybridization.
By interspecific backcross analysis using progeny derived from matings of C57BL/6J and M. spretus, MacGregor et al. (1992) mapped the Crabp2 to chromosome 2, linked to muscle nicotinic acetylcholine receptor alpha-chain (Acra) and catalase-1 (Cas1).
Elder, J. T., Astrom, A., Pettersson, U., Voorhees, J. J., Trent, J. M. Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. Hum. Genet. 89: 487-490, 1992. [PubMed: 1321791] [Full Text: https://doi.org/10.1007/BF00219171]
Flagiello, D., Apiou, F., Gibaud, A., Poupon, M. F., Dutrillaux, B., Malfoy, B. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. Cytogenet. Cell Genet. 76: 17-18, 1997. [PubMed: 9154115] [Full Text: https://doi.org/10.1159/000134502]
Giguere, V., Lyn, S., Yip, P., Siu, C.-H., Amin, S. Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc. Nat. Acad. Sci. 87: 6233-6237, 1990. [PubMed: 2166951] [Full Text: https://doi.org/10.1073/pnas.87.16.6233]
MacGregor, T. M., Copeland, N. G., Jenkins, N. A., Giguere, V. The murine gene for cellular retinoic acid-binding protein type II: genomic organization, chromosomal localization, and post-transcriptional regulation by retinoic acid. J. Biol. Chem. 267: 7777-7783, 1992. [PubMed: 1313808]