Entry - *180386 - LIM DOMAIN ONLY 3; LMO3 - OMIM
 
* 180386

LIM DOMAIN ONLY 3; LMO3


Alternative titles; symbols

RHOMBOTIN-LIKE-2; RBTNL2
RHOMBOTIN 3; RBTN3; RHOM3


HGNC Approved Gene Symbol: LMO3

Cytogenetic location: 12p12.3     Genomic coordinates (GRCh38): 12:16,548,372-16,610,174 (from NCBI)


TEXT

Cloning and Expression

Boehm et al. (1991) identified LMO3, a member of the rhombotin family (see LMO1; 186921) of cysteine-rich LIM domain oncogenes.

Rabbitts et al. (1991) found that the RHOM3 gene was transcribed mainly in the brain.

Using subtractive hybridization to identify genes upregulated by dopamine in rat cerebral astrocytes, followed by screening a human fetal brain cDNA library, Shi et al. (2001) cloned LMO3.


Mapping

Rabbitts et al. (1991) found that the RHOM3 gene is located on chromosome 12p13.


REFERENCES

  1. Boehm, T., Foroni, L., Kaneko, Y., Perutz, M. F., Rabbitts, T. H. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Nat. Acad. Sci. 88: 4367-4371, 1991. [PubMed: 2034676, related citations] [Full Text]

  2. Rabbitts, T., Boehm, T., Perutz, M., Kaneko, Y. Rhom-3, a gene which is highly related to rhombotin and located on chromosome 12p13. (Abstract) Cytogenet. Cell Genet. 58: 80 only, 1991.

  3. Shi, J., Cai, W., Chen, X., Ying, K., Zhang, K., Xie, Y. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. Brain Res. 910: 29-37, 2001. [PubMed: 11489251, related citations] [Full Text]


Contributors:
Patricia A. Hartz - updated : 5/8/2007
Creation Date:
Victor A. McKusick : 6/12/1991
mgross : 06/06/2007
terry : 5/8/2007
carol : 8/21/1998
dkim : 7/7/1998
supermim : 3/16/1992
carol : 2/23/1992
carol : 2/18/1992
carol : 6/12/1991

* 180386

LIM DOMAIN ONLY 3; LMO3


Alternative titles; symbols

RHOMBOTIN-LIKE-2; RBTNL2
RHOMBOTIN 3; RBTN3; RHOM3


HGNC Approved Gene Symbol: LMO3

Cytogenetic location: 12p12.3     Genomic coordinates (GRCh38): 12:16,548,372-16,610,174 (from NCBI)


TEXT

Cloning and Expression

Boehm et al. (1991) identified LMO3, a member of the rhombotin family (see LMO1; 186921) of cysteine-rich LIM domain oncogenes.

Rabbitts et al. (1991) found that the RHOM3 gene was transcribed mainly in the brain.

Using subtractive hybridization to identify genes upregulated by dopamine in rat cerebral astrocytes, followed by screening a human fetal brain cDNA library, Shi et al. (2001) cloned LMO3.


Mapping

Rabbitts et al. (1991) found that the RHOM3 gene is located on chromosome 12p13.


REFERENCES

  1. Boehm, T., Foroni, L., Kaneko, Y., Perutz, M. F., Rabbitts, T. H. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Nat. Acad. Sci. 88: 4367-4371, 1991. [PubMed: 2034676] [Full Text: https://doi.org/10.1073/pnas.88.10.4367]

  2. Rabbitts, T., Boehm, T., Perutz, M., Kaneko, Y. Rhom-3, a gene which is highly related to rhombotin and located on chromosome 12p13. (Abstract) Cytogenet. Cell Genet. 58: 80 only, 1991.

  3. Shi, J., Cai, W., Chen, X., Ying, K., Zhang, K., Xie, Y. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. Brain Res. 910: 29-37, 2001. [PubMed: 11489251] [Full Text: https://doi.org/10.1016/s0006-8993(01)02393-9]


Contributors:
Patricia A. Hartz - updated : 5/8/2007

Creation Date:
Victor A. McKusick : 6/12/1991

Edit History:
mgross : 06/06/2007
terry : 5/8/2007
carol : 8/21/1998
dkim : 7/7/1998
supermim : 3/16/1992
carol : 2/23/1992
carol : 2/18/1992
carol : 6/12/1991