HGNC Approved Gene Symbol: RPL4
Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,498,015-66,504,855 (from NCBI)
Bagni et al. (1993) cloned and sequenced a cDNA encoding human ribosomal protein L4. The corresponding mRNA had a very short 5-prime untranslated region initiated by a sequence of 12 pyrimidines characteristic of all vertebrate ribosomal protein mRNAs. Interspecies comparisons demonstrated that the N-terminal region is very conserved and the C-terminal portion highly divergent. The RPL4 protein has 427 amino acids and a calculated molecular mass of 47,821 Da.
By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi et al. (1998) mapped the RPL4 gene to chromosome 15q.
Bagni, C., Mariottini, P., Annesi, F., Amaldi, F. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. Biochim. Biophys. Acta 1216: 475-478, 1993. [PubMed: 8268230] [Full Text: https://doi.org/10.1016/0167-4781(93)90017-8]
Kenmochi, N., Kawaguchi, T., Rozen, S., Davis, E., Goodman, N., Hudson, T. J., Tanaka, T., Page, D. C. A map of 75 human ribosomal protein genes. Genome Res. 8: 509-523, 1998. [PubMed: 9582194] [Full Text: https://doi.org/10.1101/gr.8.5.509]