Alternative titles; symbols
HGNC Approved Gene Symbol: RPLP1
Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,452,818-69,456,205 (from NCBI)
Acidic ribosomal proteins, called A-proteins or P-proteins, are generally present in multiple copies on the ribosome and have isoelectric points in the range of pH 3 to 5, in contrast to most ribosomal proteins, which are single copy and basic. A-proteins have hydrophobic amino acid compositions, notably about 20% alanine (summary by Rich and Steitz, 1987).
Rich and Steitz (1987) described the isolation and analysis of 3 cDNA molecules that encode the human P-proteins, P2 (180530), P1, and P0 (180510). The human P1 and P2 cDNA nucleotide sequences and deduced amino acid sequences of the proteins are very similar to the sequences that have been determined for the corresponding rat, shrimp, and yeast proteins and cDNAs. P0 sequences had not previously been described. To demonstrate that the coding sequences are full length, Rich and Steitz (1987) transcribed the P0, P1, and P2 cDNAs in vitro. The P0, P1, and P2 proteins produced were serologically and electrophoretically identical to P-proteins extracted from HeLa cells. The deduced P1 protein contains 114 amino acids. Northern blot analysis revealed expression of a 0.65-kb transcript in HeLa cells.
Stumpf (2021) mapped the RPLP1 gene to chromosome 15q23 based on an alignment of the RPLP1 sequence (GenBank BC003369) with the genomic sequence (GRCh38).
Rich, B. E., Steitz, J. A. Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. Molec. Cell. Biol. 7: 4065-4074, 1987. [PubMed: 3323886] [Full Text: https://doi.org/10.1128/mcb.7.11.4065-4074.1987]
Stumpf, A. M. Personal Communication. Baltimore, Md. 09/28/2021.