Alternative titles; symbols
HGNC Approved Gene Symbol: SNORA62
Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,411,054-39,411,207 (from NCBI)
See 180645. Several of the known small nucleolar RNA (snoRNA) species have been shown to be required for processing of ribosomal RNA (rRNA) precursors. The genes of most of the known vertebrate snoRNA species are located in introns of mRNA precursors (Maxwell and Fournier, 1995). E2 RNA is a nucleolar species that is 154-nucleotides long in the human. Selvamurugan and Eliceiri (1995) stated that it belongs to a new family of snoRNAs because it does not have the sequences named 'box C,' 'C-prime,' or 'D' that are present in most vertebrate snoRNA species, and it does not bind fibrillarin (134795), the nucleolar protein associated with most snoRNAs. E2 snoRNA is found in all tissues tested in all vertebrates analyzed. Two observations are compatible with the possibility that the human E2 RNA gene may be intronic. First, the human gene lacks the intragenic flanking sequences that are functional in other genes. Second, the 5-prime end of E2 RNA is monophosphorylated, suggesting that it is formed by RNA processing. Intron-encoded snoRNAs have monophosphorylated 5-prime termini. Selvamurugan and Eliceiri (1995) demonstrated that the E2 gene resides in an intron of a laminin-binding protein, the 67-kD laminin receptor (LAMR1; 150370). Multiple copies (up to 16) of the LAMR1 gene per haploid genome are present in the human.
Maxwell, E. W., Fournier, M. J. The small nucleolar RNAs. Annu. Rev. Biochem. 64: 897-934, 1995. [PubMed: 7574504] [Full Text: https://doi.org/10.1146/annurev.bi.64.070195.004341]
Selvamurugan, N., Eliceiri, G. L. The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene. Genomics 30: 400-401, 1995. [PubMed: 8586453]