Alternative titles; symbols
HGNC Approved Gene Symbol: SNORA63
Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,787,299-186,787,433 (from NCBI)
Ruff et al. (1993) identified 3 small nucleolar RNAs in human cells that they named E1 (SNORA73A; 180645), E2 (SNORA62; 180646), and E3 (SNORA63). Their unique sequences implied that they are members of another class of small nuclear RNAs. Their 5-prime termini are not capped, they are present at low levels in vertebrate cells, and they appear to be 'housekeeping' RNAs, since they were expressed in all tissues examined. They may function in some aspects of ribosome formation, since in addition to being detected only in the nucleolar fraction, they are psoralen-photocrosslinked in vivo to unique segments of pre-rRNA.
Nag et al. (1993) reported the isolation and expression of human genes encoding the E1, E2, and E3 snoRNAs. The presence of a monophosphate at the 5-prime end of each of the 3 snoRNAs suggested that their 5-prime termini are formed by RNA processing. Substantial sequence homology was found between the human E3 gene and its flanking regions and intron 8 and neighboring exons of the gene for mouse translation initiation factor 4AII (EIF4A2; 601102).
Gross (2011) mapped the SNORA63 gene to chromosome 3q27.3 based on an alignment of the SNORA63 sequence (GenBank L07384) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 4/29/2011.
Nag, M. K., Thai, T. T., Ruff, E. A., Selvamurugan, N., Kunnimalaiyaan, M., Eliceiri, G. L. Genes for E1, E2, and E3 small nucleolar RNAs. Proc. Nat. Acad. Sci. 90: 9001-9005, 1993. [PubMed: 8415643] [Full Text: https://doi.org/10.1073/pnas.90.19.9001]
Ruff, E. A., Rimoldi, O. J., Raghu, B., Eliceiri, G. L. Three small nucleolar RNAs of unique nucleotide sequences. Proc. Nat. Acad. Sci. 90: 635-638, 1993. [PubMed: 8421699] [Full Text: https://doi.org/10.1073/pnas.90.2.635]