Alternative titles; symbols
HGNC Approved Gene Symbol: SNORD3A
Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,188,016-19,188,232 (from NCBI)
U3 RNA, an abundant small nucleolar RNA (snoRNA), is thought to play a role in the processing of ribosomal RNA precursors (Bernstein et al., 1983).
Chevillard et al. (1993) demonstrated that the RNU3 gene is located at chromosome 17p12-p11.2, a region that is deleted in Smith-Magenis syndrome (182290). This region is proximal to the site of the CMT1A gene (601097).
Bernstein, L. B., Mount, S. M., Weiner, A. M. Pseudogenes for human small nuclear RNA U3 appear to arise by integration of self-primed reverse transcripts of the RNA into new chromosomal sites. Cell 32: 461-472, 1983. [PubMed: 6186397] [Full Text: https://doi.org/10.1016/0092-8674(83)90466-x]
Chevillard, C., Le Paslier, D., Passage, E., Ougen, P., Billault, A., Boyer, S., Mazan, S., Bachellerie, J. P., Vignal, A., Cohen, D., Fontes, M. Relationship between Charcot-Marie-Tooth 1A and Smith-Magenis regions: snU3 may be a candidate gene for the Smith-Magenis syndrome. Hum. Molec. Genet. 2: 1235-1243, 1993. [PubMed: 8401506] [Full Text: https://doi.org/10.1093/hmg/2.8.1235]
Denison, R. A., van Arsdell, S. W., Bernstein, L. B., Weiner, A. M. Abundant pseudogenes for small nuclear RNAs are dispersed in the human genome. Proc. Nat. Acad. Sci. 78: 810-814, 1981. [PubMed: 6165010] [Full Text: https://doi.org/10.1073/pnas.78.2.810]
Suh, D., Busch, H., Reddy, R. Human U3 small nucleolar RNA genes are localized to the nucleoplasm. Biochem. Biophys. Res. Commun. 143: 658-664, 1987. [PubMed: 3566742] [Full Text: https://doi.org/10.1016/0006-291x(87)91404-5]