Alternative titles; symbols
HGNC Approved Gene Symbol: HTR1E
Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:86,937,528-87,016,679 (from NCBI)
Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter thought to play a role in various cognitive and behavioral functions including feeding, sleep, pain, depression, and learning. Serotonin receptors have been divided into classes depending on their ligand binding and effector-coupling properties (summary by McAllister et al., 1992).
McAllister et al. (1992) stated the 5-HT-1 receptor family can be further subdivided into 4 subtypes, 5-HT-1A to 5-HT-1D. McAllister et al. (1992) described the cloning and characterization of a 5-HT-1E receptor. The excellent correlation observed between the pharmacology of the expressed receptor and the human brain 5-HT-1E binding site confirmed that their clone encodes a 5-HT-1E receptor and establishes a fifth 5-HT-1-like receptor subtype. HTR1E is found mainly in the cerebral cortex.
Using 2 independent polymerase chain reactions on a panel of human-hamster somatic cell hybrid genomic DNA, Levy et al. (1994) showed that the 5-hydroxytryptamine-1E serotonin receptor gene is located on human chromosome 6. Furthermore, by means of in situ hybridization to human metaphase chromosomes using the cloned gene as a probe (Levy et al., 1992), they demonstrated that the gene is located on 6q14-q15.
Levy, F. O., Gudermann, T., Birnbaumer, M., Kaumann, A. J., Birnbaumer, L. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett. 296: 201-206, 1992. [PubMed: 1733778] [Full Text: https://doi.org/10.1016/0014-5793(92)80379-u]
Levy, F. O., Holtgreve-Grez, H., Tasken, K., Solberg, R., Ried, T., Gudermann, T. Assignment of the gene encoding the 5-HT-1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. Genomics 22: 637-640, 1994. [PubMed: 8001977] [Full Text: https://doi.org/10.1006/geno.1994.1439]
McAllister, G., Charlesworth, A., Snodin, C., Beer, M. S., Noble, A. J., Middlemiss, D. N., Iversen, L. L., Whiting, P. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc. Nat. Acad. Sci. 89: 5517-5521, 1992. [PubMed: 1608964] [Full Text: https://doi.org/10.1073/pnas.89.12.5517]