Alternative titles; symbols
HGNC Approved Gene Symbol: HTR1D
Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,191,895-23,217,502 (from NCBI)
The serotonin 1D receptor was initially characterized by radioligand binding procedures using membranes derived from bovine caudate nucleus. The 5-HT-1D receptor is known to be a G protein-coupled receptor. Sumatriptan, an agent effective in the treatment of acute migraine, is the only ligand yet identified that is selective for the 5-HT-1D receptor. Weinshank et al. (1992) reported the cloning, deduced amino acid sequences, pharmacologic properties, and second-messenger coupling of a pair of human 5-HT-1D receptor genes, which they designated alpha and beta due to their strong similarities. Both genes have no introns in their coding regions, are expressed in the human cerebral cortex, and can couple to inhibition of adenylate cyclase activity. Their pharmacologic binding properties match closely those of human, bovine, and guinea pig 5-HT-1D sites. Libert et al. (1991) obtained cDNA clones encoding 4 receptors of the G protein-coupled receptor family by selective amplification and cloning from thyroid cDNA. One of these clones, termed RDC4 by them, showed close structural similarity with the serotonin 5HT1A receptor (109760). By in situ hybridization, they demonstrated that the gene (HTR1D) is located on chromosome 1 at 1p36.3-p34.3. By Southern blot analysis of a hybrid cell panel, Jin et al. (1992) showed that the HTR1D gene is located on chromosome 1. Wilkie et al. (1993) showed that the homologous gene in the mouse is located on chromosome 4.
Jin, H., Oksenberg, D., Ashkenazi, A., Peroutka, S. J., Duncan, A. M. V., Rozmahel, R., Yang, Y., Mengod, G., Palacios, J. M., O'Dowd, B. F. Characterization of the human 5-hydroxytryptamine(1B) receptor. J. Biol. Chem. 267: 5735-5738, 1992. [PubMed: 1348246]
Libert, F., Passage, E., Parmentier, M., Simons, M.-J., Vassart, G., Mattei, M.-G. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. Genomics 11: 225-227, 1991. Note: Erratum: Genomics 23: 305 only, 1994. [PubMed: 1662665] [Full Text: https://doi.org/10.1016/0888-7543(91)90125-x]
Weinshank, R. L., Zgombick, J. M., Macchi, M. J., Branchek, T. A., Hartig, P. R. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT(1D-alpha) and 5-HT(1D-beta). Proc. Nat. Acad. Sci. 89: 3630-3634, 1992. [PubMed: 1565658] [Full Text: https://doi.org/10.1073/pnas.89.8.3630]
Wilkie, T. M., Chen, Y., Gilbert, D. J., Moore, K. J., Yu, L., Simon, M. I., Copeland, N. G., Jenkins, N. A. Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics 18: 175-184, 1993. [PubMed: 8288218] [Full Text: https://doi.org/10.1006/geno.1993.1452]