Alternative titles; symbols
HGNC Approved Gene Symbol: HTR1F
Cytogenetic location: 3p11.2-p11.1 Genomic coordinates (GRCh38): 3:87,792,706-87,993,839 (from NCBI)
Lovenberg et al. (1993) isolated a novel G protein-coupled serotonin receptor, which they called MR77, of the 5-HT-1 class. MR77 was expressed at low levels throughout the brain, with the greatest expression in the cortex, hippocampus, and striatum. HeLa cells transfected with the MR77 gene exhibited inhibition of adenylate cyclase in response to serotonin. Human MR77 is 86% and 93% identical to rat MR77 at the nucleic acid and amino acid sequence levels, respectively. Its amino acid sequence showed the greatest similarity to HTR1E (182132). Amlaiky et al. (1992) described the mouse homolog.
Using a monochromosomal mapping panel, followed by a radiation-reduced hybrid mapping and fluorescence in situ hybridization, VanDenBrink et al. (1998) mapped the HTR1F gene to 3p12.
Exclusion Studies
VanDenBrink et al. (1998) investigated the presence of polymorphisms in the HTR1F gene by SSCP analysis in 14 migraine patients who consistently responded well to sumatriptan, 12 patients who consistently experienced recurrence of the headache after initial relief, 12 patients with no response to sumatriptan, and 13 patients who consistently experienced chest symptoms after use of sumatriptan. No polymorphisms were detected in any of the patients. They therefore concluded that genetic diversity of the HTR1F gene is probably not responsible for the variable clinical response to the drug.
Amlaiky, N., Ramboz, S., Boschert, U., Plassat, J.-L., Hen, R. Isolation of a mouse '5HT1E-like' serotonin receptor expressed predominantly in hippocampus. J. Biol. Chem. 267: 19761-19764, 1992. [PubMed: 1328180]
Lovenberg, T. W., Erlander, M. G., Baron, B. M., Racke, M., Slone, A. L., Siegel, B. W., Craft, C. M., Burns, J. E., Danielson, P. E., Sutcliffe, J. G. Molecular cloning and functional expression of 5-HT-1E-like rat and human 5-hydroxytryptamine receptor genes. Proc. Nat. Acad. Sci. 90: 2184-2188, 1993. [PubMed: 8384716] [Full Text: https://doi.org/10.1073/pnas.90.6.2184]
VanDenBrink, A. M., Vergouwe, M. N., Ophoff, R. A., Naylor, S. L., Dauwerse, H. G., Saxena, P. R., Ferrari, M. D., Frants, R. R. Chromosomal localization of the 5-HT(1F) receptor gene: no evidence for involvement in response to sumatriptan in migraine patients. Am. J. Med. Genet. 77: 415-420, 1998. [PubMed: 9632173]