Alternative titles; symbols
HGNC Approved Gene Symbol: SEMG1
Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,207,033-45,209,768 (from NCBI)
Lilja et al. (1989) isolated clones for semenogelin, the predominant protein in human semen, from a seminal vesicular cDNA library. One clone carrying a cDNA insert of 1,606 nucleotides and a polyadenylated tail coded for the entire semenogelin precursor. An open reading frame of 1,386 nucleotides encoded a signal peptide and a mature protein of 439 amino acid residues, in which residues 85 to 136 were identical with a previously characterized semenogelin fragment. An abundant seminal vesicular mRNA transcript of 1.8 kb codes for semenogelin. Two additional transcripts, one a seminal vesicular 2.2-kb species and one an epididymal 2.0-kb species, code for related proteins that have both structural and antigenic features in common with semenogelin. Semenogelin and the semenogelin-related proteins are the major proteins involved in the gelatinous entrapment of ejaculated spermatozoa. The spermatozoa become progressively motile as these gel-forming proteins are fragmented by the kallikrein-like protease, prostate-specific antigen (176820), and the gel dissolves.
Ulvsback et al. (1992) cloned the 2 semenogelin genes, SEMG1 and SEMG2 (182141).
Ulvsback et al. (1992) demonstrated that the SEMG1 and SEMG2 genes are located 11.5 kb apart on chromosome 20q12-q13.1.
Lilja, H., Abrahamsson, P.-A., Lundwall, A. Semenogelin, the predominant protein in human semen: primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J. Biol. Chem. 264: 1894-1900, 1989. [PubMed: 2912989]
Ulvsback, M., Lazure, C., Lilja, H., Spurr, N. K., Rao, V. V., Loffler, C., Hansmann, I., Lundwall, A. Gene structure of semenogelin I and II: the predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J. Biol. Chem. 267: 18080-18084, 1992. [PubMed: 1517240] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0021-9258(19)37155-8]