Alternative titles; symbols
HGNC Approved Gene Symbol: CCL1
Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,360,328-34,363,233 (from NCBI)
The inflammatory cytokine I-309 is one of the small inducible chemotactic and inflammatory peptides which have a hydrophobic leader sequence typical of secreted proteins; in many cases the products have indeed been demonstrated to be secreted. Comparison of amino acid sequences of the gene products show that they share numerous conserved amino acids, most notably 4 cysteine residues that are arranged in a characteristic motif. The superfamily is divided into 2 subfamilies, which are called CC or CXC, depending on whether the protein has 2 adjacent cysteine residues or has a single amino acid separating the 2 cysteine residues, respectively. Three characterized members of the CXC family, platelet factor-4 (173460), INP10 (147310), and MGSA (155730), have been mapped to chromosome 4, whereas members of the CC family, such as RANTES (187011), have been mapped to chromosome 17. By study of a panel of rodent-human somatic cell hybrids, Miller et al. (1990) mapped the gene for I309 (SCYA1), a small secreted protein produced by activated human T-lymphocytes, to chromosome 17. I309 is structurally related to the CXC group of proteins. The homologous mouse gene is termed Tca-3.
Miller, M. D., Wilson, S. D., Dorf, M. E., Seuanez, H. N., O'Brien, S. J., Krangel, M. S. Sequence and chromosomal location of the I-309 gene: relationship to genes encoding a family of inflammatory cytokines. J. Immun. 145: 2737-2744, 1990. [PubMed: 2212659]