Alternative titles; symbols
HGNC Approved Gene Symbol: FKBP2
Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,241,095-64,244,135 (from NCBI)
For background information on FK506-binding proteins (FKBPs), see FKBP1A (186945).
Jin et al. (1991) reported the cloning and subcellular localization of a 13-kD FK506-binding protein (FKBP13), which has a 21-amino acid signal peptide and appears to be membrane-associated. The 120-amino acid mature protein appears to lack a transmembrane domain but a potential endoplasmic reticulum retention sequence (arg-thr-glu-leu) is found at its C terminus. FKBP13 shares 51% nucleotide sequence identity and 43% amino acid sequence identity with FKBP12 (FKBP1; 186945), the predominant FK506- and rapamycin-binding protein in human T cells. Jin et al. (1991) noted that conserved residues that comprise the drug binding site and rotamase active site of FKBP12 are completely conserved in FKBP13.
DiLella et al. (1992) found that the FKBP2 gene is 3 kb long and contains 6 exons.
By fluorescence in situ hybridization, DiLella et al. (1992) mapped the FKBP2 gene to 11q13.1-q13.3.
Courseaux et al. (1996) used a combination of methods to refine maps of the approximately 5-Mb region of 11q13 that includes MEN1 (131100). They proposed the following gene order: cen--PGA--FTH1--UGB--AHNAK--ROM1--MDU1--CHRM1--COX8--EMK1--FKBP2--PLCB3--[PYGM, ZFM1]--FAU--CAPN1--[MLK3, RELA]--FOSL1--SEA--CFL1--tel.
Courseaux, A., Grosgeorge, J., Gaudray, P., Pannett, A. A. J., Forbes, S. A., Williamson, C., Bassett, D., Thakker, R. V., Teh, B. T., Farnebo, F., Shepherd, J., Skogseid, B., Larsson, C., Giraud, S., Zhang, C. X., Salandre, J., Calender, A. Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. Genomics 37: 354-365, 1996. [PubMed: 8938448]
DiLella, A. G., Hawkins, A., Craig, R. J., Schreiber, S. L., Griffin, C. A. Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. Biochem. Biophys. Res. Commun. 189: 819-823, 1992. [PubMed: 1281998] [Full Text: https://doi.org/10.1016/0006-291x(92)92276-4]
Jin, Y.-J., Albers, M. W., Lane, W. S., Bierer, B. E., Schreiber, S. L., Burakoff, S. J. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. Proc. Nat. Acad. Sci. 88: 6677-6681, 1991. [PubMed: 1713687] [Full Text: https://doi.org/10.1073/pnas.88.15.6677]