HGNC Approved Gene Symbol: DYNLT2
Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:169,725,091-169,751,572 (from NCBI)
Rappold et al. (1987) cloned and characterized a gene with male germ cell-specific expression, symbolized TCTE3, from the t-complex on mouse chromosome 17. The significance of the testis-specific expression of TCTE3, particularly in later spermatogenic stages, was supported by its genetic mapping to a subregion of about 1 cM in the middle of the t-complex, called In(17)3, which contains the distorter/sterility gene Tcd-3. This locus on mouse chromosome 17 is involved in distortion of transmission ratios and male sterility.
Rappold et al. (1992) used somatic cell hybrid lines to map the human TCTE3 gene to the long arm of chromosome 6. By chromosomal in situ hybridization, the assignment was refined to the very distal portion of 6q27. Thus, the TCTE3 gene is close to the TCP1 (186980) and TCP10 (187020) genes, which are also homologs of t-complex loci. In contrast, the TCTE1 gene (186975) and some others are on 6p, indicating a syntenic homology between the proximal and middle portions of the t-complex of mouse chromosome 17 and 6q and between the distal portion of the t-complex and 6p.
Rappold, G. A., Stubbs, L., Labeit, S., Crkvenjakov, R. B., Lehrach, H. Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island. EMBO J. 6: 1975-1980, 1987. [PubMed: 3653077] [Full Text: https://doi.org/10.1002/j.1460-2075.1987.tb02460.x]
Rappold, G. A., Trowsdale, J., Lichter, P. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. Genomics 13: 1337-1339, 1992. [PubMed: 1505969] [Full Text: https://doi.org/10.1016/0888-7543(92)90062-w]