HGNC Approved Gene Symbol: TMSB10
Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:84,905,656-84,906,671 (from NCBI)
The TMSB10 gene encodes thymosin-beta-10, an actin-sequestering protein (summary by Lin and Morrison-Bogorad, 1991).
Lin and Morrison-Bogorad (1991) noted that cDNAs encoding thymosin beta-10 had been isolated from cDNA libraries of rat spleen, fetal rat brain, and human kidney. The predicted protein is closely related in sequence to TMSB4 and is also an actin-sequestering protein. In most tissues of the rat, the same molecular weight species of TMSB10 mRNA is found; Lin and Morrison-Bogorad (1990) identified an additional TMSB10 mRNA of higher molecular weight in the testis of sexually mature rats. Lin and Morrison-Bogorad (1991) found that this mRNA differed from the ubiquitous form only in its 5-prime untranslated region, beginning 14 nucleotides upstream of the translation initiation codon. This finding, together with primer extension experiments, suggested that the 2 mRNAs are transcribed from the same gene through a combination of differential promoter utilization and alternative splicing. Both mRNAs were present in pachytene spermatocytes; only the testis-specific mRNA was detected in postmeiotic haploid spermatids. Immunohistochemical analysis showed that the protein was present in differentiating spermatids, suggesting that the testis-specific TMSB10 mRNA is translated in haploid male germ cells. Immunoblot analysis using specific antibodies showed that the thymosin-beta-10 protein synthesized in adult testis was identical in size to that synthesized in brain.
Lin, S.-C., Morrison-Bogorad, M. Cloning and characterization of a testis-specific thymosin beta-10 cDNA: expression in post-meiotic male germ cells. J. Biol. Chem. 266: 23347-23353, 1991. [PubMed: 1744129]
Lin, S.-C., Morrison-Bogorad, M. Developmental expression of mRNAs encoding thymosins beta-4 and beta-10 in rat brain and other tissues. J. Molec. Neurosci. 2: 35-44, 1990. [PubMed: 1979498] [Full Text: https://doi.org/10.1007/BF02896924]