Alternative titles; symbols
HGNC Approved Gene Symbol: TRK-TTT3-5
Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,119,155-8,119,227 (from NCBI)
Morrison et al. (1989) investigated a cluster of tRNA genes, including TRK1. In situ hybridization with biotin labeling permitted localization to 17pter-p12. By means of a somatic cell hybrid mapping panel, Morrison et al. (1991) confirmed and refined the assignment to 17p13.1.
Bourn et al. (1994) determined that the first 4 genes of the cluster, TRL2 (189920), TRK1, TRQ1 (189919), and TRR1 (610406) are separated from the TRG2 gene (610407) by a CpG island, and they are copied at least 2 and possibly 3 times within chromosome 17p13.1. All 5 genes are further copied in other arrangements within the same small chromosomal region; the TRK1 gene is copied a minimum of 9 times.
Bourn, D., Carr, T., Livingstone, D., McLaren, A., Goddard, J. P. An intron-containing tRNA(Arg) gene within a large cluster of human tRNA genes. DNA Seq. 5: 83-92, 1994. [PubMed: 7703509] [Full Text: https://doi.org/10.3109/10425179409039709]
Morrison, N., Goddard, J. P., Bourn, D., Connor, J. M., Boyd, E. Chromosomal assignment to 17p12-17pter of a tRNA gene cluster (a leucine tRNA, a glutamine tRNA, and a lysine tRNA). (Abstract) Cytogenet. Cell Genet. 51: 1048 only, 1989.
Morrison, N., Goddard, J. P., Ledbetter, D. H., Boyd, E., Bourn, D., Connor, J. M. Chromosomal assignment of a large tRNA gene cluster (tRNA-leu, tRNA-gln, tRNA-lys, tRNA-arg, tRNA-gly) to 17p13.1. Hum. Genet. 87: 226-230, 1991. [PubMed: 2066114] [Full Text: https://doi.org/10.1007/BF00204190]