Entry - *189919 - tRNA GLUTAMINE (ANTICODON CTG) 1-5; TRQ-CTG1-5 - OMIM

 
 
* 189919

tRNA GLUTAMINE (ANTICODON CTG) 1-5; TRQ-CTG1-5


Alternative titles; symbols

tRNA-GLN (ANTICODON CTG) 1-5
TRANSFER RNA GLUTAMINE 1; TRNAQ1
tRNA GLUTAMINE 1; TRQ1


HGNC Approved Gene Symbol: TRQ-CTG1-5

Cytogenetic location: 17p13.1     Genomic coordinates (GRCh38): 17:8,119,752-8,119,823 (from NCBI)


TEXT

▼ Mapping

Morrison et al. (1988, 1989) investigated a cluster of tRNA genes, including TRQ1. In situ hybridization with biotin labeling permitted localization to 17pter-p12. By means of a somatic cell hybrid mapping panel, Morrison et al. (1991) confirmed and refined the assignment to 17p13.100-p13.105. See also TRL2, 189920.


▼ Gene Structure

Bourn et al. (1994) determined that the first 4 genes of the cluster, TRL2, TRK1 (189918), TRQ1, and TRR1 (610406) are separated from the TRG2 gene (610407) by a CpG island, and they are copied at least 2 and possibly 3 times within chromosome 17p13.1. All 5 genes are further copied in other arrangements within the same small chromosomal region; the TRQ2 gene is copied a minimum of 10 times.


▼ REFERENCES

  1. Bourn, D., Carr, T., Livingstone, D., McLaren, A., Goddard, J. P. An intron-containing tRNA(Arg) gene within a large cluster of human tRNA genes. DNA Seq. 5: 83-92, 1994. [PubMed: 7703509, related citations] [Full Text]

  2. Morrison, N., Goddard, J., Connor, J. M., Boyd, E. Chromosomal assignment of a tRNA gene cluster (tRNA-Leu, tRNA-Gln, tRNA-Lys) to 17p12-pter. (Abstract) Clinical Genetics Society, Aberdeen, Scotland 1988.

  3. Morrison, N., Goddard, J. P., Bourn, D., Connor, J. M., Boyd, E. Chromosomal assignment to 17p12-17pter of a tRNA gene cluster (a leucine tRNA, a glutamine tRNA, and a lysine tRNA). (Abstract) Cytogenet. Cell Genet. 51: 1048 only, 1989.

  4. Morrison, N., Goddard, J. P., Ledbetter, D. H., Boyd, E., Bourn, D., Connor, J. M. Chromosomal assignment of a large tRNA gene cluster (tRNA-leu, tRNA-gln, tRNA-lys, tRNA-arg, tRNA-gly) to 17p13.1. Hum. Genet. 87: 226-230, 1991. [PubMed: 2066114, related citations] [Full Text]


Contributors:
Patricia A. Hartz - updated : 9/14/2006
Creation Date:
Victor A. McKusick : 3/7/1990
Edit History:
mgross : 01/08/2021
carol : 10/14/2016
alopez : 04/04/2012
carol : 8/31/2009
wwang : 9/14/2006
alopez : 7/26/1999
dkim : 7/16/1998
supermim : 3/16/1992
supermim : 3/20/1990
carol : 3/7/1990

* 189919

tRNA GLUTAMINE (ANTICODON CTG) 1-5; TRQ-CTG1-5


Alternative titles; symbols

tRNA-GLN (ANTICODON CTG) 1-5
TRANSFER RNA GLUTAMINE 1; TRNAQ1
tRNA GLUTAMINE 1; TRQ1


HGNC Approved Gene Symbol: TRQ-CTG1-5

Cytogenetic location: 17p13.1     Genomic coordinates (GRCh38): 17:8,119,752-8,119,823 (from NCBI)


TEXT

Mapping

Morrison et al. (1988, 1989) investigated a cluster of tRNA genes, including TRQ1. In situ hybridization with biotin labeling permitted localization to 17pter-p12. By means of a somatic cell hybrid mapping panel, Morrison et al. (1991) confirmed and refined the assignment to 17p13.100-p13.105. See also TRL2, 189920.


Gene Structure

Bourn et al. (1994) determined that the first 4 genes of the cluster, TRL2, TRK1 (189918), TRQ1, and TRR1 (610406) are separated from the TRG2 gene (610407) by a CpG island, and they are copied at least 2 and possibly 3 times within chromosome 17p13.1. All 5 genes are further copied in other arrangements within the same small chromosomal region; the TRQ2 gene is copied a minimum of 10 times.


REFERENCES

  1. Bourn, D., Carr, T., Livingstone, D., McLaren, A., Goddard, J. P. An intron-containing tRNA(Arg) gene within a large cluster of human tRNA genes. DNA Seq. 5: 83-92, 1994. [PubMed: 7703509] [Full Text: https://doi.org/10.3109/10425179409039709]

  2. Morrison, N., Goddard, J., Connor, J. M., Boyd, E. Chromosomal assignment of a tRNA gene cluster (tRNA-Leu, tRNA-Gln, tRNA-Lys) to 17p12-pter. (Abstract) Clinical Genetics Society, Aberdeen, Scotland 1988.

  3. Morrison, N., Goddard, J. P., Bourn, D., Connor, J. M., Boyd, E. Chromosomal assignment to 17p12-17pter of a tRNA gene cluster (a leucine tRNA, a glutamine tRNA, and a lysine tRNA). (Abstract) Cytogenet. Cell Genet. 51: 1048 only, 1989.

  4. Morrison, N., Goddard, J. P., Ledbetter, D. H., Boyd, E., Bourn, D., Connor, J. M. Chromosomal assignment of a large tRNA gene cluster (tRNA-leu, tRNA-gln, tRNA-lys, tRNA-arg, tRNA-gly) to 17p13.1. Hum. Genet. 87: 226-230, 1991. [PubMed: 2066114] [Full Text: https://doi.org/10.1007/BF00204190]


Contributors:
Patricia A. Hartz - updated : 9/14/2006

Creation Date:
Victor A. McKusick : 3/7/1990

Edit History:
mgross : 01/08/2021
carol : 10/14/2016
alopez : 04/04/2012
carol : 8/31/2009
wwang : 9/14/2006
alopez : 7/26/1999
dkim : 7/16/1998
supermim : 3/16/1992
supermim : 3/20/1990
carol : 3/7/1990



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 29, 2024