Alternative titles; symbols
Cytogenetic location: Chr.12 Genomic coordinates (GRCh38): 12:1-133,275,309
Dobner et al. (1987) cloned the TUBAL1 gene, which they designated H-alpha-44, as the human homolog of the mouse M-alpha-4 gene. H-alpha-44 appeared to have the same gene organization and transcription pattern as M-alpha-4. Villasante et al. (1986) had found that the mouse tubulin gene M-alpha-4 is transcribed as 2 different mRNAs: a 1.8-kb transcript that is present in all somatic tissues and a 2.4-kb transcript that is present primarily in testis. The 2.4-kb mRNA lacks an ATG initiator codon and appears to be transcribed from a different promoter.
Gatti et al. (1987) described a biallelic DNA polymorphism of an alpha-tubulin gene and showed that the polymorphic fragments were localized to chromosome 12 when hybridized to DNA from 18 mouse/human hybrid cells. In addition, invariant bands, termed M and N, were found to be located on chromosomes 11 and 12, respectively.
Dobner, P. R., Kislauskis, E., Wentworth, B. M., Villa-Komaroff, L. Alternative 5-prime exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region. Nucleic Acids Res. 15: 199-218, 1987. [PubMed: 3029670] [Full Text: https://doi.org/10.1093/nar/15.1.199]
Gatti, R. A., Shaked, R., Wei, S., Mohandas, T. K., Salser, W. Biallelic DNA polymorphism of an alpha-tubulin gene family member on chromosome 12. Nucleic Acids Res. 15: 8119 only, 1987. [PubMed: 2444926] [Full Text: https://doi.org/10.1093/nar/15.19.8119]
Gozes, I., Barnstable, C. J. Monoclonal antibodies that recognize discrete forms of tubulin. Proc. Nat. Acad. Sci. 79: 2579-2583, 1982. [PubMed: 6178107] [Full Text: https://doi.org/10.1073/pnas.79.8.2579]
Little, M., Luduena, R. F., Keenan, R., Asnes, C. F. Tubulin evolution: two major types of alpha-tubulin. J. Molec. Evol. 19: 80-86, 1982. [PubMed: 6761444] [Full Text: https://doi.org/10.1007/BF02100226]
Villasante, A., Wang, D., Dobner, P., Dolph, P., Lewis, S. A., Cowan, N. J. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Molec. Cell. Biol. 6: 2409-2419, 1986. [PubMed: 3785200] [Full Text: https://doi.org/10.1128/mcb.6.7.2409-2419.1986]
Wilde, C. D., Chow, L. T., Wefald, F. C., Cowan, N. J. Structure of two human alpha-tubulin genes. Proc. Nat. Acad. Sci. 79: 96-100, 1982. [PubMed: 6275393] [Full Text: https://doi.org/10.1073/pnas.79.1.96]