Alternative titles; symbols
HGNC Approved Gene Symbol: VIPR1
Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,489,299-42,537,568 (from NCBI)
Vasoactive intestinal peptide (VIP; 192320) has potent relaxing effects on vascular and nonvascular smooth muscle, regulates water and ion flux from lung and intestinal epithelia, promotes neuronal growth and survival, and modulates immune functions. Distinct subsets of neural, respiratory, gastrointestinal, and immune cells bear specific high-affinity G protein-coupled receptors for VIP, such as VIPR1 (Sreedharan et al., 1995).
Sreedharan et al. (1993) cloned a human intestinal VIP receptor gene; the deduced amino acid sequence shares 84% identity with the rat lung VIP receptor.
Couvineau et al. (1994) isolated 2 VIPR cDNA clones from a human jejunal epithelial cell cDNA library. One encodes a VIP receptor consisting of 460 amino acids and having 7 putative transmembrane domains, as do other G protein-coupled receptors. The other encodes a 495-amino acid VIP receptor-related protein exhibiting 100% homology with the functional VIP receptor over the 428 amino acids at the C-terminal region, but containing a completely divergent 67-amino acid N-terminal domain. When expressed in COS-7 cells, the second protein did not bind radioiodinated VIP, although it was normally addressed at the plasma membrane as assessed by immunofluorescence studies.
Sreedharan et al. (1995) determined that the VIPR1 gene spans approximately 22 kb and contains 13 exons (ranging from 42 to 1,400 bp). Sreedharan et al. (1995) also characterized the promoter and the 5-prime flanking region of the gene.
Using FISH, Sreedharan et al. (1995) mapped the VIPR1 gene to chromosome 3p22 in a region associated with small-cell lung cancer. By interspecific backcross analysis, Hashimoto et al. (1999) mapped the mouse Vipr1 gene to the distal region of chromosome 9, which shows homology of synteny with human chromosome 3p.
Couvineau, A., Rouyer-Fessard, C., Darmoul, D., Maoret, J.-J., Carrero, I., Ogier-Denis, E., Laburthe, M. Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. Biochem. Biophys. Res. Commun. 200: 769-776, 1994. [PubMed: 8179610] [Full Text: https://doi.org/10.1006/bbrc.1994.1517]
Hashimoto, H., Nishino, A., Shintani, N., Hagihara, N., Copeland, N. G., Jenkins, N. A., Yamamoto, K., Matsuda, T., Ishihara, T., Nagata, S., Baba, A. Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC-1) receptor. Genomics 58: 90-93, 1999. [PubMed: 10331949] [Full Text: https://doi.org/10.1006/geno.1999.5805]
Sreedharan, S. P., Huang, J.-X., Cheung, M.-C., Goetzl, E. J. Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. Proc. Nat. Acad. Sci. 92: 2939-2943, 1995. [PubMed: 7708752] [Full Text: https://doi.org/10.1073/pnas.92.7.2939]
Sreedharan, S. P., Patel, D. R., Huang, J.-X., Goetzl, E. J. Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. Biochem. Biophys. Res. Commun. 193: 546-553, 1993. [PubMed: 8390245] [Full Text: https://doi.org/10.1006/bbrc.1993.1658]