HGNC Approved Gene Symbol: ZNF2
Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,165,809-95,184,317 (from NCBI)
The 'finger' motif, a loop-like domain formed by the interaction of 2 invariant pairs of cysteines and histidines with a zinc atom, has been proposed as a novel protein structure capable of specific interaction with DNA (Miller et al., 1985). Regulatory proteins containing 'finger' domains have been identified in many species from yeast to vertebrates. A subset of these proteins contains a highly conserved amino acid stretch that connects repetitive zinc-binding domains. Using as a probe a mouse DNA segment containing multiple copies of this 7-amino acid domain, Archidiacono et al. (1989) selected several clones from a human liver cDNA library. One of the clones used as a probe, called A1-5, was found to contain 3 'finger' domains, and by study of a panel of human-hamster cell hybrids, Archidiacono et al. (1989) showed that the corresponding gene is located on chromosome 2. By fluorescence in situ hybridization, Rocchi et al. (1999) localized the ZNF2 gene to 2q11.2.
Archidiacono, N., Grimaldi, G., Rocchi, M., Romeo, G. Mapping of three sequenced clones coding for Zn(++) finger proteins. Cytogenet. Cell Genet. 51: 952 only, 1989.
Miller, J., McLachlan, A. D., Klug, A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 4: 1609-1614, 1985. [PubMed: 4040853] [Full Text: https://doi.org/10.1002/j.1460-2075.1985.tb03825.x]
Rocchi, M., Gentile, E., Rosati, M., Grimaldi, G. The human KRAB/FPB containing zinc finger gene ZNF2 maps to chromosome 2q11.2. Cytogenet. Cell Genet. 86: 305-306, 1999. [PubMed: 10575230] [Full Text: https://doi.org/10.1159/000015323]