HGNC Approved Gene Symbol: ZNF3
Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,063,837-100,082,577 (from NCBI)
Using a consensus sequence of a mouse zinc finger motif as probe, Pannuti et al. (1988) obtained a partial clone of ZNF3, which they called cHF.12, from a placenta cDNA library. ZNF3 has at least 6 finger repeats. Northern blot analysis of mRNA from cell lines of various tissue origin showed ubiquitous expression of a 3.5-kb transcript. Expression of ZNF3 was drastically reduced upon terminal differentiation of 2 human myeloid cell lines.
Using a cDNA probe isolated from a human liver cDNA library by means of a mouse DNA segment containing multiple copies of a 7-amino acid zinc finger domain, for the study of human-hamster cell hybrids, Archidiacono et al. (1989) showed that one sequence identified by probe A8-51 is located on chromosome 5.
Stumpf (2023) mapped the ZNF3 gene to chromosome 7q22.1 based on an alignment of the ZNF3 sequence (GenBank BC013603) with the genomic sequence (GRCh38).
Archidiacono, N., Grimaldi, G., Rocchi, M., Romeo, G. Mapping of three sequenced clones coding for Zn(++) finger proteins. Cytogenet. Cell Genet. 51: 952 only, 1989.
Pannuti, A., Lanfrancone, L., Pascucci, A., Pelicci, P.-G., La Mantia, G., Lania, L. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. Nucleic Acids Res. 16: 4227-4237, 1988. [PubMed: 3380682] [Full Text: https://doi.org/10.1093/nar/16.10.4227]
Stumpf, A. M. Personal Communication. Baltimore, Md. 11/17/2023.