Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF33B
Cytogenetic location: 10q11.21 Genomic coordinates (GRCh38): 10:42,574,169-42,638,570 (from NCBI)
By a combination of in situ chromosomal hybridization and somatic cell hybrid analysis, Rousseau-Merck et al. (1992) concluded that there are sequences hybridizing to the KOX2 probe at 2 loci, which they called ZNF11A (ZNF33A; 194521) and ZNF11B (ZNF33B), that map proximal and distal to a 10q11.2 breakpoint, respectively. They suggested that the 2 ZNF11 loci represent related sequences. Rousseau-Merck et al. (1992) suggested that this cluster of zinc finger protein genes (ZNF11, ZNF22 (194529), and ZNF25 (194528)) is of particular interest since the loci for MEN2A and MEN2B map to this region.
Tunnacliffe et al. (1993) identified 2 related zinc finger gene clusters mapping to the pericentromeric region of chromosome 10. Cluster A contains ZNF11A (ZNF33A) and ZNF37A (616085) and maps to chromosome 10p11.2. Cluster B contains ZNF11B (ZNF33B) and ZNF37B and maps to chromosome 10q11.2. Southern blot analysis indicated that the 2 clusters evolved by duplication of an ancestral gene cluster before the divergence of the human and great ape lineages.
Rousseau-Merck, M. F., Tunnacliffe, A., Berger, R., Ponder, B. A. J., Thiesen, H. J. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Genomics 13: 845-848, 1992. [PubMed: 1639412] [Full Text: https://doi.org/10.1016/0888-7543(92)90166-p]
Tunnacliffe, A., Liu, L., Moore, J. K., Leversha, M. A., Jackson, M. S., Papi, L., Ferguson-Smith, M. A., Thiesen, H.-J., Ponder, B. A. J. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Nucleic Acids Res. 21: 1409-1417, 1993. [PubMed: 8464732] [Full Text: https://doi.org/10.1093/nar/21.6.1409]