Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF18
Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:11,977,439-12,021,527 (from NCBI)
Zinc finger proteins are regulatory transcription factors that interact directly with DNA and/or RNA. Among the different human Kox cDNAs encoding zinc finger structures isolated from cell lines of T cell origin, Rousseau-Merck et al. (1991, 1993) demonstrated that ZNF18 (Kox 11) maps to 17p13-p12 in the same region as ZNF29 (194535) and TP53 (191170). ZFP3 (194480) maps to the same region. Mapping was performed by analysis of somatic cell hybrids and in situ hybridization. From somatic cell hybrid analysis, Huebner et al. (1991) concluded that the order is 17pter--TP53, ZNF18--ZNF29--p12.
Huebner, K., Druck, T., Croce, C. M., Thiesen, H. J. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Am. J. Hum. Genet. 48: 726-740, 1991. [PubMed: 2014798]
Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Berger, R., Thiesen, H. J. Chromosomal localization of two human zinc finger protein genes (Kox), to chromosome 17p13p12. (Abstract) Cytogenet. Cell Genet. 58: 2009, 1991.
Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Couillin, P., Seite, P., Thiesen, H.-J., Berger, R. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Hum. Genet. 92: 583-587, 1993. [PubMed: 8262519] [Full Text: https://doi.org/10.1007/BF00420943]