Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF23
Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,447,597-71,462,247 (from NCBI)
Zhou et al. (2002) cloned ZNF359 from a human heart cDNA library. The deduced protein contains KRAB A and KRAB B motifs in the N terminus and 16 tandemly repeated kruppel-type zinc finger motifs in the C terminus. Northern blot analysis detected expression of a 3.2-kb transcript in various adult tissues, with highest expression in skeletal muscle, heart, liver, and pancreas. Further analyses in embryonic tissues (18-23 weeks) showed a development-specific expression pattern in heart, skeletal muscle, liver, lung, kidney, and brain.
Cannizzaro et al. (1993) mapped a member of the KOX gene family, ZNF23 (KOX16), to chromosome 16q22 by in situ hybridization. The map location is near 2 fragile sites, FRA16B and FRA16C. The 16q22 region is involved, furthermore, in chromosomal alterations characteristic of acute myeloid leukemia. The ZNF19 gene (194525) maps to the same region. Analogous genes in the mouse map to chromosome 8 in a region of syntenic homology. By pulsed field gel electrophoresis experiments, Rousseau-Merck et al. (1993) showed that the ZNF19 and ZNF23 genes lie within a 200-300 kb DNA fragment.
Cannizzaro, L. A., Aronson, M. M., Thiesen, H. J. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. Hum. Genet. 91: 383-385, 1993. [PubMed: 8500793] [Full Text: https://doi.org/10.1007/BF00217362]
Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Couillin, P., Seite, P., Thiesen, H.-J., Berger, R. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Hum. Genet. 92: 583-587, 1993. [PubMed: 8262519] [Full Text: https://doi.org/10.1007/BF00420943]
Zhou, L., zhu, C., Luo, K., Li, Y., Pi, H., Yuan, W., Wang, Y., Huang, C., Liu, M., Wu, X. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. Biochem. Biophys. Res. Commun. 295: 862-868, 2002. [PubMed: 12127974] [Full Text: https://doi.org/10.1016/s0006-291x(02)00759-3]