Entry - *194532 - ZINC FINGER PROTEIN 8; ZNF8 - OMIM

 
 
* 194532

ZINC FINGER PROTEIN 8; ZNF8


HGNC Approved Gene Symbol: ZNF8

Cytogenetic location: 19q13.43     Genomic coordinates (GRCh38): 19:58,278,955-58,302,791 (from NCBI)


TEXT

▼ Cloning and Expression

The zinc finger DNA-binding motif is found in a variety of transcriptional regulatory proteins. By screening a placenta library with the zinc finger-encoding region of the HF10 (ZNF35; 194533) cDNA, Lania et al. (1990) isolated a ZNF7 (194531) cDNA and a partial ZNF8 cDNA. The predicted ZNF8 protein contains 7 zinc finger domains. Northern blot analysis revealed that ZNF8 is expressed as 2.2- and 11-kb mRNAs in various human cell lines.


▼ Mapping

By in situ hybridization, Lania et al. (1990) mapped the ZNF8 gene to chromosome 20q13. However, Gross (2011) mapped the ZNF8 gene to chromosome 19q13.43 based on an alignment of the ZNF8 sequence (GenBank BC039323) with the genomic sequence (GRCh37).


▼ REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 2/7/2011.

  2. Lania, L., Donti, E., Pannuti, A., Pascucci, A., Pengue, G., Feliciello, I., La Mantia, G., Lanfrancone, L., Pelicci, P.-G. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Genomics 6: 333-340, 1990. [PubMed: 2106481, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 02/07/2011
Rebekah S. Rasooly - updated : 5/18/1999
Creation Date:
Victor A. McKusick : 2/11/1990
Edit History:
mgross : 02/07/2011
alopez : 7/7/2010
alopez : 5/18/1999
alopez : 5/18/1999
dkim : 6/25/1998
supermim : 3/16/1992
supermim : 3/20/1990
supermim : 3/1/1990
supermim : 2/11/1990

* 194532

ZINC FINGER PROTEIN 8; ZNF8


HGNC Approved Gene Symbol: ZNF8

Cytogenetic location: 19q13.43     Genomic coordinates (GRCh38): 19:58,278,955-58,302,791 (from NCBI)


TEXT

Cloning and Expression

The zinc finger DNA-binding motif is found in a variety of transcriptional regulatory proteins. By screening a placenta library with the zinc finger-encoding region of the HF10 (ZNF35; 194533) cDNA, Lania et al. (1990) isolated a ZNF7 (194531) cDNA and a partial ZNF8 cDNA. The predicted ZNF8 protein contains 7 zinc finger domains. Northern blot analysis revealed that ZNF8 is expressed as 2.2- and 11-kb mRNAs in various human cell lines.


Mapping

By in situ hybridization, Lania et al. (1990) mapped the ZNF8 gene to chromosome 20q13. However, Gross (2011) mapped the ZNF8 gene to chromosome 19q13.43 based on an alignment of the ZNF8 sequence (GenBank BC039323) with the genomic sequence (GRCh37).


REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 2/7/2011.

  2. Lania, L., Donti, E., Pannuti, A., Pascucci, A., Pengue, G., Feliciello, I., La Mantia, G., Lanfrancone, L., Pelicci, P.-G. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Genomics 6: 333-340, 1990. [PubMed: 2106481] [Full Text: https://doi.org/10.1016/0888-7543(90)90574-e]


Contributors:
Matthew B. Gross - updated : 02/07/2011
Rebekah S. Rasooly - updated : 5/18/1999

Creation Date:
Victor A. McKusick : 2/11/1990

Edit History:
mgross : 02/07/2011
alopez : 7/7/2010
alopez : 5/18/1999
alopez : 5/18/1999
dkim : 6/25/1998
supermim : 3/16/1992
supermim : 3/20/1990
supermim : 3/1/1990
supermim : 2/11/1990



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 5, 2024