Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF35
Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,646,506-44,660,791 (from NCBI)
Zinc fingers are protein DNA-binding domains that consist of tandemly repeated units of 28 to 30 amino acids containing 2 cysteine and 2 histidine residues at invariant positions. The finger motif has been identified in several eukaryotic transcriptional regulatory proteins and members of the finger-gene family are implicated in both proliferation and differentiation of normal cells. By means of hybridization with a finger motif-containing DNA probe, Donti et al. (1990) identified several human finger genes, one of which, HF.10, is expressed at low levels in a variety of human tissues and is downregulated during the in vitro terminal differentiation of human leukemic myeloid cell lines.
Lanfrancone et al. (1992) reported that the ZNF35 gene spans about 13 kb and is interrupted by 3 introns. All 11 zinc finger DNA-binding domains are contiguously encoded within the last 3-prime exon.
Using in situ hybridization, Lanfrancone et al. (1992) showed that both the functional ZNF35 locus and a processed pseudogene map to chromosome 3p22-p21, a region that is frequently deleted in small cell lung cancer and renal carcinoma. Both the functional gene and the pseudogene were deleted in a case of small cell lung carcinoma with 3p deletion.
By in situ hybridization and by analysis of interspecific somatic cell hybrids, Donti et al. (1990) mapped the HF10 gene to 3p22-p21, a chromosome region frequently involved in karyotypic changes associated with lung and renal cancer. Hoovers et al. (1992) also assigned zinc finger protein genes to 3p.
Calabro et al. (1995) isolated 3 new genes encoding zinc finger proteins from a YAC contig of 3p22-p21 by using a cDNA hybridization selection. They took this to indicate a clustering of zinc finger protein genes in 3p21.
Calabro, V., Pengue, G., Bartoli, P. C., Pagliuca, A., Featherstone, T., Lania, L. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. Hum. Genet. 95: 18-21, 1995. [PubMed: 7814019] [Full Text: https://doi.org/10.1007/BF00225067]
Donti, E., Lanfrancone, L., Huebner, K., Pascucci, A., Venti, G., Pengue, G., Grignani, F., Croce, C. M., Lania, L., Pelicci, P. G. Localization of the human HF.10 finger gene on a chromosome region (3p21-p22) frequently deleted in human cancers. Hum. Genet. 84: 391-395, 1990. [PubMed: 2108922] [Full Text: https://doi.org/10.1007/BF00195806]
Hoovers, J. M. N., Mannens, M., John, R., Bliek, J., van Heyningen, V., Porteous, D. J., Leschot, N. J., Westerveld, A., Little, P. F. R. High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered. Genomics 12: 254-263, 1992. [PubMed: 1740334] [Full Text: https://doi.org/10.1016/0888-7543(92)90372-y]
Lanfrancone, L., Pengue, G., Pandolfi, P.-P., Salcini, A. E., Giacomucci, A., Longo, L., Donti, E., De Luca, P., La Mantia, G., Pelicci, P.-G., Lania, L. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. Genomics 12: 720-728, 1992. [PubMed: 1572646] [Full Text: https://doi.org/10.1016/0888-7543(92)90301-8]