Entry - *194536 - ZINC FINGER PROTEIN 12; ZNF12 - OMIM

 
 
* 194536

ZINC FINGER PROTEIN 12; ZNF12


Alternative titles; symbols

KOX3


HGNC Approved Gene Symbol: ZNF12

Cytogenetic location: 7p22.1     Genomic coordinates (GRCh38): 7:6,688,433-6,706,947 (from NCBI)


TEXT

▼ Mapping

Seite et al. (1991) localized 1 member of the human zinc finger Kruppel family, ZNF12 (KOX3), to chromosome 7p22-p21 by a combination of analysis of mouse-human somatic cell hybrids and in situ hybridization. Rousseau-Merck et al. (1993) described pulsed field gel electrophoresis experiments indicating that ZNF12 and ZNF26 (194537) are within the same DNA fragment less than 300 kb long.


▼ History

The control of gene expression in prokaryotes and eukaryotes is mediated, at least in part, by the binding of regulatory proteins to specific DNA sequences. Many of these proteins share evolutionarily conserved DNA binding domains, e.g. homeodomains (Gehring, 1987) or zinc finger structures (Schuh et al., 1986). These homologies have been used to clone individual genes of these multigene families from higher eukaryotic organisms.


▼ REFERENCES

  1. Gehring, W. J. Homeo boxes in the study of development. Science 236: 1245-1252, 1987. [PubMed: 2884726, related citations] [Full Text]

  2. Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Couillin, P., Seite, P., Thiesen, H.-J., Berger, R. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Hum. Genet. 92: 583-587, 1993. [PubMed: 8262519, related citations] [Full Text]

  3. Schuh, R., Aicher, W., Gaul, U., Cote, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schroder, C., Kemler, R., Jackle, H. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Kruppel, a Drosophila segmentation gene. Cell 47: 1025-1032, 1986. [PubMed: 3096579, related citations] [Full Text]

  4. Seite, P., Huebner, K., Rousseau-Merck, M. F., Berger, R., Thiesen, H. J. Two human genes encoding zinc finger proteins, ZNF12 (KOX3) and ZNF26 (KOX20), map to chromosomes 7p22-p21 and 12q24.33, respectively. Hum. Genet. 86: 585-590, 1991. [PubMed: 2026422, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 5/28/1991
Edit History:
alopez : 07/07/2010
terry : 3/19/2004
dkim : 6/25/1998
mark : 5/14/1996
carol : 2/24/1994
supermim : 3/16/1992
carol : 5/28/1991

* 194536

ZINC FINGER PROTEIN 12; ZNF12


Alternative titles; symbols

KOX3


HGNC Approved Gene Symbol: ZNF12

Cytogenetic location: 7p22.1     Genomic coordinates (GRCh38): 7:6,688,433-6,706,947 (from NCBI)


TEXT

Mapping

Seite et al. (1991) localized 1 member of the human zinc finger Kruppel family, ZNF12 (KOX3), to chromosome 7p22-p21 by a combination of analysis of mouse-human somatic cell hybrids and in situ hybridization. Rousseau-Merck et al. (1993) described pulsed field gel electrophoresis experiments indicating that ZNF12 and ZNF26 (194537) are within the same DNA fragment less than 300 kb long.


History

The control of gene expression in prokaryotes and eukaryotes is mediated, at least in part, by the binding of regulatory proteins to specific DNA sequences. Many of these proteins share evolutionarily conserved DNA binding domains, e.g. homeodomains (Gehring, 1987) or zinc finger structures (Schuh et al., 1986). These homologies have been used to clone individual genes of these multigene families from higher eukaryotic organisms.


REFERENCES

  1. Gehring, W. J. Homeo boxes in the study of development. Science 236: 1245-1252, 1987. [PubMed: 2884726] [Full Text: https://doi.org/10.1126/science.2884726]

  2. Rousseau-Merck, M.-F., Hillion, J., Jonveaux, P., Couillin, P., Seite, P., Thiesen, H.-J., Berger, R. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Hum. Genet. 92: 583-587, 1993. [PubMed: 8262519] [Full Text: https://doi.org/10.1007/BF00420943]

  3. Schuh, R., Aicher, W., Gaul, U., Cote, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schroder, C., Kemler, R., Jackle, H. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Kruppel, a Drosophila segmentation gene. Cell 47: 1025-1032, 1986. [PubMed: 3096579] [Full Text: https://doi.org/10.1016/0092-8674(86)90817-2]

  4. Seite, P., Huebner, K., Rousseau-Merck, M. F., Berger, R., Thiesen, H. J. Two human genes encoding zinc finger proteins, ZNF12 (KOX3) and ZNF26 (KOX20), map to chromosomes 7p22-p21 and 12q24.33, respectively. Hum. Genet. 86: 585-590, 1991. [PubMed: 2026422] [Full Text: https://doi.org/10.1007/BF00201545]


Creation Date:
Victor A. McKusick : 5/28/1991

Edit History:
alopez : 07/07/2010
terry : 3/19/2004
dkim : 6/25/1998
mark : 5/14/1996
carol : 2/24/1994
supermim : 3/16/1992
carol : 5/28/1991



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 19, 2024