Alternative titles; symbols
Cytogenetic location: 6p21.3 Genomic coordinates (GRCh38): 6:30,500,001-36,600,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 6p21.3 | {Lysis by alloreactive natural killer cells, susceptibility to} | 272370 | Autosomal recessive | 2 |
Susceptibility to lysis by alloreactive natural killer (NK) cells is an autosomal recessive trait (thus differing from the behavior of conventional MHC products) (Ciccone et al., 1990; Ciccone et al., 1990).
Ciccone et al. (1990) mapped the locus for susceptibility to lysis by alloreactive natural killer cells, termed EC1, to chromosome 6. Ciccone et al. (1990) mapped it to the major histocompatibility complex region with its centromeric limit at BF (138470). Ciccone et al. (1990) raised the possibility that 'hybrid resistance' in mice (Hh-I) may be the homologous state and noted that the Hh-I alloantigens are recessively inherited and encoded in the murine MHC on chromosome 17.
Ciccone, E., Colonna, M., Viale, O., Pende, D., Di Donato, C., Reinharz, D., Amoroso, A., Jeannet, M., Guardiola, J., Moretta, A., Spies, T., Strominger, J., Moretta, L. Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B. Proc. Nat. Acad. Sci. 87: 9794-9797, 1990. Note: Erratum: Proc. Nat. Acad. Sci. 88: 5477 only, 1991. [PubMed: 1979875] [Full Text: https://doi.org/10.1073/pnas.87.24.9794]
Ciccone, E., Pende, D., Viale, O., Tambussi, G., Ferrini, S., Biassoni, R., Longo, A., Guardiola, J., Moretta, A., Moretta, L. Specific recognition of human CD3(-)CD16+ natural killer cells requires the expression of an autosomic (sic) recessive gene on target cells. J. Exp. Med. 172: 47-52, 1990. [PubMed: 1694227] [Full Text: https://doi.org/10.1084/jem.172.1.47]