HGNC Approved Gene Symbol: NAP1L3
Cytogenetic location: Xq21.32 Genomic coordinates (GRCh38): X:93,670,930-93,673,578 (from NCBI)
The nucleosome, which is composed of DNA and histones, is a characteristic feature of eukaryotic cells, constituting not only a structural unit of the chromosome but a regulator of gene expression. From a human fetal brain cDNA library, Watanabe et al. (1996) isolated a novel gene sharing significant homology with the genes of nucleosome assembly proteins (NAPs). This 2.6-kb cDNA clone, designated NAP1L3, encodes a 506-amino acid protein. Its predicted amino acid sequence shows 46% identity and 65% similarity to that of NAP1L (164060). Northern blot analysis revealed strong expression of a 3-kb transcript in human adult brain, weak expression in heart, and no detectable transcript in other tissues tested.
By PCR amplification of radiation hybrid clones, Watanabe et al. (1996) mapped the NAP1L3 gene to Xq21.3-q22.
Watanabe, T. K., Fujiwara, T., Nakamura, Y., Hirai, Y., Maekawa, H., Takahashi, E. Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins. Cytogenet. Cell Genet. 74: 281-285, 1996. [PubMed: 8976385] [Full Text: https://doi.org/10.1159/000134435]