HGNC Approved Gene Symbol: MYCLP1
Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:107,272,464-107,276,556 (from NCBI)
Morton et al. (1989) characterized a DNA sequence with homology to the MYC family of protooncogenes and found that it is a processed gene related to LMYC (MYCL1; 164850). This processed gene, designated MYCL2, was isolated by cross hybridization to an oligonucleotide probe synthesized from the MYC sequence in a highly conserved region. MYCL2 has an open reading frame of 1,194 basepairs with strong homology to the sequence of MYCL1.
By 5-prime RACE of adult testis total RNA, Robertson et al. (1991) cloned MYCL2. Like MYCL1, the deduced MYCL2 protein has a basic region followed by a helix-loop-helix motif and a C-terminal leucine zipper. RNase protection and Northern blot analyses of normal tissues detected a 4.8-kb MYCL2 transcript only in adult testis. Weak MYCL2 expression was detected in a lung adenocarcinoma.
Robertson et al. (1991) found that MYCL2 is an intronless gene that may have multiple transcription start sites in a GC-rich region. MYCL2 lacks appropriately spaced TATAA or CAAT boxes.
By somatic cell hybrid analysis, Morton et al. (1989) mapped the MYCL2 gene to chromosome Xq22-q28.
Using PCR with a series of hybrids carrying different portions of the human X chromosome, Redolfi et al. (1999) mapped the MYCL2 gene to chromosome Xq22-q23. They mapped a related pseudogene, MYCL3, to chromosome Xq27.2.
Morton, C. C., Nussenzweig, M. C., Sousa, R., Sorenson, G. D., Pettengill, O. S., Shows, T. B. Mapping and characterization of an X-linked processed gene related to MYCL1. Genomics 4: 367-375, 1989. [PubMed: 2541066] [Full Text: https://doi.org/10.1016/0888-7543(89)90344-3]
Redolfi, E., Pizzuti, A., Di Bacco, A., Susani, L., Labella, T., Affer, M., Montagna, C., Reinbold, R., Mumm, S., Vezzoni, P., Zucchi, I. Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2. FEBS Lett. 446: 273-277, 1999. [PubMed: 10100857] [Full Text: https://doi.org/10.1016/s0014-5793(99)00243-4]
Robertson, N. G., Pomponio, R. J., Mutter, G. L., Morton, C. C. Testis-specific expression of the human MYCL2 gene. Nucleic Acids Res. 19: 3129-3137, 1991. [PubMed: 1711681] [Full Text: https://doi.org/10.1093/nar/19.11.3129]